134331-45-6

Basic information

• Product Name: N-benzoylglycylglycyl-S-butylisothiourea
• CAS NO: 134331-45-6
• Molecular Weight: 350.442
• Mol File: 134331-45-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-benzoylglycylglycyl-S-butylisothiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoylglycylglycyl-S-butylisothiourea(134331-45-6)
• EPA Substance Registry System: N-benzoylglycylglycyl-S-butylisothiourea(134331-45-6)

Safety Data

• Hazardous Substances Data: 134331-45-6(Hazardous Substances Data)

Upstream product

• 1145-32-0 N-(N'-benzoyl-2-aminoethanoyl)-2-aminoethanoic acid 
• 57303-58-9 S-butylisothiourea hydrogen iodide 
• 42940-69-2 isobutyl chlorocarbonate 

Relevant articles and documents

C-terminal Sequencing of Peptides: An Investigation of the Iminohydantoin Method

A method for the C-terminal sequencing of peptides was briefly outlined at a conference in 1975, but no further results have been reported since.This method converts the carboxy group into an acyl-S-alkylisothioureide, which on treatment with base reportedly gives the acylcyanamide.Following cyclization and hydrolysis, the iminohydantoin corresponding to the C-terminal residue is formed.Thus the peptide chain is shortened by one residue at each cycle.Using model peptides, we have prepared authentic samples of the supposed products at each step, and have shown thatthe acylcyanamide is not an intermediate in this reaction.With glycine as the C-terminal residue, the iminohydantoin is obtained in near-quantitative yield.