134440-89-4

Basic information

• Product Name: (2R,3S)-3-methoxy-2-methyl-4-phenylbutanal
• Synonyms: (2R,3S)-3-methoxy-2-methyl-4-phenylbutanal
• CAS NO: 134440-89-4
• Molecular Weight: 192.258
• Mol File: 134440-89-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-methoxy-2-methyl-4-phenylbutanal(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-methoxy-2-methyl-4-phenylbutanal(134440-89-4)
• EPA Substance Registry System: (2R,3S)-3-methoxy-2-methyl-4-phenylbutanal(134440-89-4)

Safety Data

• Hazardous Substances Data: 134440-89-4(Hazardous Substances Data)

Upstream product

• 118399-24-9 (S)-3-Methoxy-2-methyl-4-phenyl-butan-1-ol 
• 129371-96-6 C₁₉H₂₄O₂ 
• 126382-95-4 (2S,3S)-4-Benzyloxy-3-methyl-1-phenyl-butan-2-ol 
• 81380-12-3 (2S,3R)-3,4-epoxy-2-methyl-1-butanol benzyl ether 
• 134440-88-3 (2'R,3'S,4R,5S)-3-(3'-methoxy-2'-methyl-4'-phenylbutanoyl)-4-methyl-5-phenyloxazolidin-2-one 
• 177019-68-0 (E)-(2R,3S)-2-Methoxy-3-methyl-hex-4-enoic acid 
• 176908-03-5 (E)-(2R,3S)-2-Methoxy-3-methyl-1-phenyl-hex-4-en-1-one 
• 100-58-3 phenylmagnesium bromide 
• 122-78-1 phenylacetaldehyde 
• 184354-37-8 (2R,3S)-3-hydroxy-2-methyl-4-phenylbutan-(N-methyl-O-methyl)-hydroxamide 
• 134440-87-2 (2'R,3'S,4R,5S)-3-(3'-hydroxy-2'-methyl-4'-phenylbutanoyl)-4-methyl-5-phenyloxazolidin-2-one 
• 122332-10-9 (3S,4S)-4-hydroxy-3-methyl-5-phenylpent-1-ene 
• 101-48-4 phenylacetaldehyde dimethyl acetal 
• 211816-41-0 (3S,4S)-4-methoxy-3-methyl-5-phenylpent-1-ene 

Downstream Products

• 126399-05-1 (2E,4S,5S)-5-methoxy-2,4-dimethyl-6-phenylhex-2-en-1-ol 
• 474085-57-9 C₅₂H₈₅N₅O₁₄Si 
• 474085-61-5 2-[3-(2-{[4-(3-tert-butoxycarbonylamino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoylamino)-4-methoxycarbonyl-butyryl]-methyl-amino}-3-hydroxy-butyrylamino)-3-methoxycarbonyl-2-methyl-propionylamino]-3-methyl-butyric acid 
• 226067-32-9 C₄₉H₇₄Cl₃N₅O₁₄ 
• 226067-24-9 ((S)-1-{(2E,4E)-(1S,6S,7S)-1-[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienylcarbamoyl}-2-methyl-propyl)-carbamic acid tert-butyl ester 
• 226067-07-8 (4E,6E)-(2S,3S,8S,9S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid 
• 226067-34-1 {(S)-1-[(2E,4E)-(1S,6S,7S)-1-((S)-2-Hydroxy-1-methyl-ethyl)-7-methoxy-4,6-dimethyl-8-phenyl-octa-2,4-dienylcarbamoyl]-2-methyl-propyl}-carbamic acid tert-butyl ester 
• 194149-71-8 (E,E)-(2S,3S,8S,9S)-3-(N-tert-butoxycarbonyl)amino-1-(tert-butyl-dimethylsiloxy)-9-methoxy-10-phenyl-2,6,8-trimethyl-4,6-decadiene 
• 194149-75-2 (E,E)-(2S,3S,8S,9S)-3-(N-tert-butoxycarbonyl)amino-9-methoxy-10-phenyl-2,6,8-trimethyl-4,6-decadien-1-ol 
• 180133-61-3 (4R,5S)-4-methyl-5-methoxy-6-phenyl-2-hexyne 
• 180133-63-5 (4S,5S,2E)-2-iodo-5-methoxy-4-methyl-6-phenyl-2-hexene 
• 226067-39-6 C₄₇H₇₃N₅O₁₄ 
• 170872-85-2 dimethyl motuporine hydrate 
• 141672-08-4 (-)-motuporin 

Relevant articles and documents

Facile and rapid access to linear and truncated microcystin analogues for the implementation of immunoassays

A series of simplified microcystin-LR analogues based on Adda [(2S,3S,8S,9S,4E,6E)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldecadienoic acid] or its corresponding aldol precursor linked to a polypeptide moiety have been synthesised and assessed for thei

Total synthesis of motuporin and 5-[L-Ala]-motuporin

Total synthesis of the cyclic peptide hepatotoxin motuporin is described, including an efficient synthesis of the constituent amino acid Adda. Three strategies to motuporin are outlined with their relative strengths and weaknesses. Cyclization of the linear peptide precursor was found to proceed moderately well for peptides containing the N- methyldehydrobutyrine residue masked as a threonine, but significant C- terminal epimerization occurred in the presence of the dehydroamino acid. Replacement of the N-methyldehydrobutyrine residue by L-alanine was explored to assess the contribution of this dehydroamino acid to the biochemical activity of motuporin. Some epimerization also was observed during cyclization of the alanine-containing peptide. Synthetic motuporin and both isomers of 5-[L-Ala]-motuporin inhibit the activity of protein phosphatase-1 (PP1) in rat adipocyte lysates with comparable IC50 values. These results indicate that the N-methyldehydrobutyrine residue is not essential for PP1 inhibition.

An asymmetric synthesis of ADDA, and ADDA-glycine dipeptide using the ss-lactam synthon method

The paper describes the synthesis of the W-Boc lactam 4, and demonstrates that it is an important intermediate in the synthesis of dipeptide 5 (X = H, n = 0, R = Me), an analogue of the ADDA-GIu dipeptide 3. In addition we have described a mild method for the preparation of the amino acid salt ADDA-HC1, and provided synthetic methods, and full characterisation for the previously 'elusive' free amino acid ADDA.