13445-89-1

Basic information

• Product Name: 1-(2-AMino-3,5-dibroMo-phenyl)-ethanone
• Synonyms: 1-(2-AMino-3,5-dibroMo-phenyl)-ethanone
• CAS NO: 13445-89-1
• Molecular Formula: C₈H₇Br₂NO
• Molecular Weight: 292.95528
• Mol File: 13445-89-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 344.896°C at 760 mmHg
• Flash Point: 162.388°C
• Appearance: /
• Density: 1.883g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.638
• PKA: -0.46±0.10(Predicted)
• CAS DataBase Reference: 1-(2-AMino-3,5-dibroMo-phenyl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-AMino-3,5-dibroMo-phenyl)-ethanone(13445-89-1)
• EPA Substance Registry System: 1-(2-AMino-3,5-dibroMo-phenyl)-ethanone(13445-89-1)

Safety Data

• Hazardous Substances Data: 13445-89-1(Hazardous Substances Data)

Usage

Description

1-(2-Amino-3,5-dibromo-phenyl)-ethanone, with the molecular formula C8H8Br2NO, is a white to off-white solid chemical compound that is soluble in organic solvents such as ethanol and methanol. It is commonly utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals, and has been studied for its potential biological activities, including its role as an antiparasitic agent. Furthermore, its photophysical and photochemical properties have been investigated for applications in photodynamic therapy and other light-driven processes.

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
1-(2-Amino-3,5-dibromo-phenyl)-ethanone is used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Antiparasitic Applications:
In the field of biology, 1-(2-Amino-3,5-dibromo-phenyl)-ethanone is used as an antiparasitic agent, potentially aiding in the treatment and prevention of parasitic infections.
Used in Photodynamic Therapy:
1-(2-Amino-3,5-dibromo-phenyl)-ethanone is used in photodynamic therapy, a medical treatment that involves the use of light and photosensitizing agents to target and destroy diseased cells.
Used in Light-Driven Applications:
Due to its photophysical and photochemical properties, 1-(2-Amino-3,5-dibromo-phenyl)-ethanone is also utilized in various light-driven applications, which may include advanced materials, sensors, and other innovative technologies.

InChI:InChI=1/C8H7Br2NO/c1-4(12)6-2-5(9)3-7(10)8(6)11/h2-3H,11H2,1H3

Upstream product

• 551-93-9 2-aminoacetophenone 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 535992-33-7 1-(3,5-dibromo-2-nitro-phenyl)-ethanone 
• 29124-56-9 1-(2-amino-5-bromophenyl)ethanone 

Downstream Products

• 116772-81-7 2,3,5-tribromoacetophenone 
• 116772-88-4 C₈H₃⁽²⁾H₇O 
• 87976-29-2 benzoic-2,3,5-d3 acid 
• 33531-25-8 6,8-dibromo-2-phenyl-2,3-dihydroquinolin-4(1H)-one 
• 1421590-17-1 6,8-dibromo-4-methoxy-2-(4-methoxyphenyl)quinoline 
• 1421590-20-6 6,8-dibromo-2-(4-methoxyphenyl)quinolin-4(1H)-one 
• 1421590-16-0 6,8-dibromo-2-(4-chlorophenyl)-4-methoxyquinoline 
• 1421590-19-3 6,8-dibromo-2-(4-chlorophenyl)quinolin-4(1H)-one 
• 1421590-15-9 6,8-dibromo-2-(4-fluorophenyl)-4-methoxyquinoline 

Relevant articles and documents

A Serendipitous One-Pot Cyanation/Hydrolysis/Enamide Formation: Direct Access to 3-Methyleneisoindolin-1-ones

A direct, one-pot conversion of 2’-haloacetophenones to 3-methyleneisoindolin-1-one scaffolds using CuCN as the sole reagent without the need for moisture-free or anaerobic conditions is reported. This serendipitously discovered transformation with a broa

6,8-dibromo-4-chloroquinoline-3-carbaldehyde as a synthon in the development of novel 1,6,8-triaryl-1H-pyrazolo[4,3-c]quinolines

2-Amino-3,5-dibromoacetophenone undergoes Vilsmeier reaction with a phosphoryl chloride-dimethylformamide mixture to afford 6,8-dibromo-4- chloroquinoline-3-carbaldehyde. The latter was reacted with arylhydrazine hydrochlorides in ethanol in the presence

EPR studies of nitrogen-centred free radicals. Part 53. Isolation, EPR spectra and magnetic characterization of N-(arylthio)-2,4-diaryl-6-cyanophenylaminyls

N-(Arylthio)-2,4-diaryl-6-ethoxycarbonylphenylaminyls (1), N-[(2,4-dichlorophenyl)thio]-2,4-diphenyl-6-acetylphenylaminyl (2), N-(arylthio)-2,4-diaryl-6-cyanophenylaminyls (3), N-[(2,4-dichlorophenyl)thio]-2,4-bis(4-chlorophenyl)-6-fluorophenylaminyl (4) and N-[(4-nitrophenyl)thio]-2,4-diphenylphenylaminyl (5) were generated by oxidation of the corresponding N-(arylthio)anilines. Although 4 and 5 were short-lived and decayed in 30 min, 1-3 were quite persistent and 3 could be isolated as radical crystals. EPR spectra were measured for all radicals generated and the spin density distribution was evaluated. Ab initio MO calculations (the UHF Becke 3LYP/STO 6-31G) were performed, and a quantitative discussion on the spin density distribution was made. Magnetic susceptibility measurements were performed for three isolated radicals with a SQUID magnetometer. One radical was found to couple ferromagnetically, and analysis with the one-dimensional regular Heisenberg model gave 2J/kB = 11.2 K.