134523-02-7Relevant articles and documents
Method for purifying atorvastatin calcium intermediate
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Paragraph 0033; 0046-0047, (2021/09/01)
The atorvastatin calcium intermediate is subjected to hydrolysis reaction to obtain the reaction liquid of atorvastatin calcium intermediate. The reaction liquid is extracted with a stripping solvent and is separated and separated to obtain an aqueous pha
Preparation method of crystal form I atorvastatin calcium
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Paragraph 0069-0070; 0074-0075, (2020/02/29)
The invention discloses a preparation method of crystal form I atorvastatin calcium. The method includes the steps of: preparation of atorvastatin ester; preparation of an atorvastatin salt; preparation of atorvastatin calcium; refining an atorvastatin ca
PRODRUG OF ATROVASTATIN BY CHOLESTEROL'S SYNTHESIS INHIBITORS
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Page/Page column 13-14, (2009/05/30)
The present invention relates to atorvastatin prodrugs or pharmaceutically acceptable salts thereof. The compound of the present invention is hydrolyzed to atorvastatin in a body and allows atorvastatin to be maintained in a concentration effective in inhibiting the production of cholesterol for a long time. Further, the compound of the present invention can reduce side effects caused by an initial high concentration of atorvastatin in blood, thereby improving safety problems remarkably. Therefore, the compound of the present invention is effective in treating or preventing various diseases caused by excessive cholesterol such as hyperlipidemia, etc.