1345459-55-3

Basic information

• Product Name: 2-bromo-2,2-difluoro-N-(2-hydroxy-3-methylphenyl)acetamide
• CAS NO: 1345459-55-3
• Molecular Weight: 280.069
• Mol File: 1345459-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-2,2-difluoro-N-(2-hydroxy-3-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-2,2-difluoro-N-(2-hydroxy-3-methylphenyl)acetamide(1345459-55-3)
• EPA Substance Registry System: 2-bromo-2,2-difluoro-N-(2-hydroxy-3-methylphenyl)acetamide(1345459-55-3)

Safety Data

• Hazardous Substances Data: 1345459-55-3(Hazardous Substances Data)

Upstream product

• 95-48-7 ortho-cresol 
• 667-27-6 Ethyl bromodifluoroacetate 
• 17672-22-9 2-amino-6-methylphenol 
• 13073-29-5 2-methyl-6-nitrophenol 

Relevant articles and documents

Difluoromethylbenzoxazole pyrimidine thioether derivatives: A novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors

This paper reports the synthesis and antiviral properties of new difluoromethylbenzoxazole (DFMB) pyrimidine thioether derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. By use of a combination of structural biology study and traditional medicinal chemistry, several members of this novel class were synthesized using a single electron transfer chain process (radical nucleophilic substitution, SRN1) and were found to be potent against wild-type HIV-1 reverse transcriptase, with low cytotoxicity but with moderate activity against drug-resistant strains. The most promising compound 24 showed a significant EC50 value close to 6.4 nM against HIV-1 IIIB, a moderate EC50 value close to 54 μM against an NNRTI resistant double mutant (K103N + Y181C), but an excellent selectivity index >15477 (CC50 > 100 μM).