1345515-18-5

Basic information

• Product Name: C₈H₈ClNO
• Synonyms: C₈H₈ClNO
• CAS NO: 1345515-18-5
• Molecular Weight: 169.611
• Mol File: 1345515-18-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₈H₈ClNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₈ClNO(1345515-18-5)
• EPA Substance Registry System: C₈H₈ClNO(1345515-18-5)

Safety Data

• Hazardous Substances Data: 1345515-18-5(Hazardous Substances Data)

Upstream product

• 118-93-4 o-hydroxyacetophenone 
• 21895-22-7 2’-hydroxyacetophenone imine 
• 128-09-6 N-chloro-succinimide 

Relevant articles and documents

A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine

A divergent and regioselective synthesis of either 3-substituted benzisoxazoles or 2-substituted benzoxazoles from readily accessible ortho-hydroxyaryl N-H ketimines is described. The reaction proceeds in two distinct pathways through a common N-Cl imine intermediate: (a) N-O bond formation to form benzisoxazole under anhydrous conditions and (b) NaOCl mediated Beckmann-type rearrangement to form benzoxazole, respectively. The reaction path also depends on the electronic nature of the aromatic ring, with the electron-rich aromatic rings favoring the rearrangement and the electron-deficient rings favoring the N-O bond formation. A Beckmann-type rearrangement mechanism via net [1,2]-aryl migration for the formation of 2-substituted benzoxazole is proposed.