134563-20-5

Basic information

• Product Name: Z-Thiopro (S-oxide)-thiazolidine
• CAS NO: 134563-20-5
• Molecular Weight: 354.451
• Mol File: 134563-20-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-Thiopro (S-oxide)-thiazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Thiopro (S-oxide)-thiazolidine(134563-20-5)
• EPA Substance Registry System: Z-Thiopro (S-oxide)-thiazolidine(134563-20-5)

Safety Data

• Hazardous Substances Data: 134563-20-5(Hazardous Substances Data)

Upstream product

• 504-78-9 1,3-thiazolidine 
• 65663-71-0 Z-Thioproline S-oxide 

Relevant articles and documents

Structure activity relationship of inhibitors specific for prolyl endopeptidase.

Structural requirements of N-blocked L-proline derivatives as specific inhibitors for prolyl endopeptidase were investigated using a series of substrate analogs. Replacement of L-proline by its D-isomer remarkably reduced the inhibition. Introduction of a sulfur atom in proline and/or in the penultimate pyrrolidine rings significantly increased the inhibition, but the introduction of oxygen rather diminished the activity. A peptide linkage (acid-amide bond) between the proline and the pyrrolidine ring was also required to keep the inhibitory activity. A benzyloxycarbonyl group was most effective as an N-blocked component of the inhibitors.