1345682-63-4Relevant articles and documents
Synthesis of 3-arylthieno[2,3-b]-, -[2,3-c]- or -[3,2-c]pyridines utilizing an interrupted pummerer reaction
Kobayashi, Kazuhiro,Suzuki, Teruhiko,Horiuchi, Mai,Shiroyama, Yasuhiko,Konishi, Hisatoshi
, p. 2897 - 2906 (2011/10/18)
An efficient procedure for the synthesis of three types of thienopyridines has been developed. Thus, 3-(1-arylethenyl)-2-(ethylsulfinyl)pyridines, 4-(1-arylethenyl)-3-(ethylsulfinyl)pyridines, and 3-(1-arylethenyl)-4- (ethylsulfinyl)pyridines, which can be easily prepared from the respective aryl chloropyridinyl ketones in a three-step sequence, undergo an interrupted Pummerer reaction on treatment with excess acetic anhydride at temperatures ranging from 100 to 130 C to give 3-arylthieno[2,3-b]pyridines, 3-aryl-thieno[2,3-c]pyridines, and 3-arylthieno[3,2-c]pyridines, respectively. Georg Thieme Verlag Stuttgart - New York.
