1345697-82-6Relevant articles and documents
Room temperature N-arylation of amino acids and peptides using copper(i) and β-diketone
Sharma, Krishna K.,Sharma, Swagat,Kudwal, Anurag,Jain, Rahul
supporting information, p. 4637 - 4641 (2015/04/27)
A mild and efficient method for the N-arylation of zwitterionic amino acids, amino acid esters and peptides is described. The procedure provides the first room temperature synthesis of N-arylated amino acids and peptides using CuI as a catalyst, diketone as a ligand, and aryl iodides as coupling partners. The method is equally applicable for using relatively inexpensive aryl bromides as coupling partners at 80 °C. Using this procedure, electronically and sterically diverse aryl halides, containing reactive functional groups were efficiently coupled in good to excellent yields.
Synthesis of 1,5-benzothiazepine dipeptide mimetics via two cul-catalyzed cross coupling reactions
Gan, Jiangang,Ma, Dawel
supporting information; experimental part, p. 2788 - 2790 (2009/11/30)
Cul-catalyzed coupling of 4-methylphenyl bromide with amino acids gives N-aryl amino acids, which are converted Into linear dipeptides via lodination and condensation with L-cysteine derived acyl chloride. Cyclization Is achieved via a Cul/N,N-dimethylgly
