134575-13-6

Basic information

• Product Name: (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol
• Synonyms: (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol;cis-3-azabicyclo[3.1.0]hexan-6-ylmethanol;(1R,5S,6R)-(3-Azabicyclo[3.1.0]hex-6-yl)methanol;(1R,5S,6R)-3-Aza-6-(hydroxymethyl)bicyclo[3.1.0]hexane 95+%;(1R,5S,6R)-(3-Azabicyclo[3.1.0]hex-6-yl)methanol 95+%;(1R,5S,6R)-6-(Hydroxymethyl)-3-azabicyclo[3.1.0]hexane;exo-3-azabicyclo[3.1.0]hexane-6-Methanol;(1R,5S,6s)-3-aza-bicyclo[3.1.0]hexan-6-ylMethanol
• CAS NO: 134575-13-6
• Molecular Formula: C₆H₁₁NO
• Molecular Weight: 113.159
• Mol File: 134575-13-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 202.5 °C at 760 mmHg
• Flash Point: 110.2 °C
• Appearance: /
• Density: 1.108 g/cm³
• Vapor Pressure: 0.071mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.94±0.10(Predicted)
• CAS DataBase Reference: (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol(134575-13-6)
• EPA Substance Registry System: (1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol(134575-13-6)

Safety Data

• Hazardous Substances Data: 134575-13-6(Hazardous Substances Data)

Usage

General Description

(1R,5S,6R)-3-Azabicyclo[3.1.0]hexan-6-ylmethanol, also known as 3-Azabicyclo[3.1.0]hexane-6-methanol, is a chemical compound with the molecular formula C7H13NO. It is a bicyclic compound with a six-membered ring containing a nitrogen atom. (1R,5S,6R)-3-Azabicyclo[3.1.0]hexan-6-ylmethanol is commonly used in organic synthesis and as a building block in the preparation of pharmaceuticals and agrochemicals. Its unique structure and stereochemistry make it a versatile intermediate in the production of a variety of chemical products. Additionally, it may also have potential applications in medicinal chemistry and drug discovery due to its structural similarity to biologically active compounds.

InChI:InChI=1/C6H11NO/c8-3-6-4-1-7-2-5(4)6/h4-8H,1-3H2/t4-,5+,6+

Upstream product

• 850808-43-4 tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 13949-99-0 trans,meso-cyclopropanetricarboxylic acid triethyl ester 
• 705-35-1 trans,meso-1,2,3-cyclopropanetricarboxylic acid 
• 134575-05-6 ethyl 5-benzyl-4,6-dioxo-1,3a,4,5,6,6a-hexahydropyrrolo[3,4-c]pyrazole-3-carboxylate 
• 1366657-90-0 (1R,5S,6r)-3-benzyl-2,4-dioxo-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 187681-87-4 (1R,5S,6s)-2,4-dioxo-3-oxabicyclo[3.1.0]hexane-6-carboxylic acid 
• 134575-06-7 ethyl (1α,5α,6α)-3-benzyl-3-azabicyclo[3.1.0]hexane-2,4-dione-6-carboxylate 
• 134575-07-8 (1α,5α,6α)-6-hydroxymethyl-3-benzyl-3-aza-bicyclo[3.1.0]hexane 

Downstream Products

• 134575-14-7 benzyl (1α,5α,6α)-6-hydroxymethyl-3-azabicyclo[3.1.0]hexan-3-ylcarboxylate 
• 1173177-20-2 C₁₈H₂₄ClFN₂O₂ 
• 1173177-23-5 C₂₃H₂₈ClFN₄O₃ 
• 1173239-42-3 1-methyl-1H-imidazole-4-carboxylic acid (3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-chloro-4-fluoro-benzyl)-amide 
• 1173239-39-8 1-methyl-1H-imidazole-4-carboxylic acid (3-chloro-4-fluoro-benzyl)-(3-methyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-amide 
• 927679-54-7 (1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 1330003-88-7 1-(3-chloro-4-fluorophenyl)-N-{[(1R,5S,6s)-3-methyl-3-azabicyclo[3.1.0]hex-6-yl](2H₁)methyl}(13C,2H₂)methan(15N)amine 
• 893566-16-0 tert-butyl (1R,5S,6S)-6-(aminomethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 850808-43-4 tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 419572-19-3 (1α,5α,6α)-3-(tert-Butoxycarbonyl)-3-azabicyclo [3.1.0]hexane-6-carboxaldehyde 
• 419572-18-2 (1R,5S,6r)-tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 925457-08-5 1-(2,4-difluorophenyl)-7-[(1α,5α,6α)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 146726-08-1 (1α,5α,6α)-6-tert-butoxycarbonylamino-3-aza-bicyclo[3.1.0]hexane-3-carboxylic acid benzyl ester 
• 134575-15-8 (1α,5α,6α)-3-(benzyloxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 

Relevant articles and documents

A CLASS OF BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUNDS FOR TARGETED DEGRADATION OF ANDROGEN RECEPTORS AND USE THEREOF

The present invention relates to a class of bifunctional chimeric heterocyclic compounds for targeted degradation of androgen receptors and use thereof, and specifically provides a compound of formula (I), or an isotopic compound thereof, or an optical isomer thereof, or a tautomer thereof, or a pharmacologically acceptable salt thereof, or a prodrug thereof, or a solvate thereof, wherein ARB is an androgen receptor recognition/binding part, L is a link part, and U is a ubiquitin protease recognition/binding part; and the three parts are connected by means of chemical bonds. The compound can perform the targeted degradation on androgen receptors in prostate cancer cells, and suppress the proliferation of the prostate cancer cells, and also show good metabolic stability and pharmacokinetic properties. The compound has good application prospect in the preparation of targeted chimeras for protein degradation of androgen receptors and in the preparation of drugs for treating the related diseases regulated by the androgen receptors.

Azabicyclo quinolone carboxylic acids

Quinolone carboxylic acids 7-substituted by azabicyclo groups have antibacterial activity., Antibacterial wherein, R1 is hydrogen, a pharmaceutically acceptable cation, or alkyl;, Y, when taken independently, is ethyl, t-butyl, vinyl, cyclopropyl, 2-fluoroethyl, p-fluorophenyl, or o,p-difluorophenyl;, W is hydrogen, F, Cl, Br, alkyl, alkoxy, NH2, NHCH3;, A is CH, CF, CCl, COCH3, C-CH3, C-CN or N; or, A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five or six membered ring which may contain oxygen or a double bond, and which may have attached thereto R8 which is methyl or methylene; and, R2 is wherein R3, R4, R5, R6, R7, R9, R10 and R25 are each independently H, CH3, CH2NH2, CH2NHCH3 or CH2NHC2H5, and R5, R6, R7, and R9 may also independently be NH2, NHCH3 or NHC2H5.