1345882-95-2Relevant articles and documents
Microwave-assisted synthesis of 5-substituted 2-aminothiophenes starting from arylacetaldehydes
Revelant, Germain,Dunand, Sandrine,Hesse, Stephanie,Kirsch, Gilbert
, p. 2935 - 2940 (2011)
An easy three-step pathway for the synthesis of arylacet-aldehydes from the corresponding carboxylic acids in very high yields is described. Their use as precursors of 5-substituted-2-aminothiophenes is illustrated via a microwave-assisted Gewald reaction. This method allows obtaining the expected compounds in a shorter time and with better yields and purities than the classical procedures. Georg Thieme Verlag Stuttgart - New York.