13459-62-6

Basic information

• Product Name: Benzeneacetic acid, 2-[(4-chlorophenyl)thio]-
• Synonyms: Benzeneacetic acid, 2-[(4-chlorophenyl)thio]-;[2-[(4-Chlorophenyl)thio]phenyl]acetic acid;2-[(4-Chlorophenyl)thio]benzeneacetic acid;2-(2-((4-Chlorophenyl)thio)phenyl)acetic acid
• CAS NO: 13459-62-6
• Molecular Formula: C₁₄H₁₁ClO₂S
• Molecular Weight: 278.75394
• EINECS: -0
• Mol File: 13459-62-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 116℃
• Boiling Point: 434.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 4.13±0.10(Predicted)
• CAS DataBase Reference: Benzeneacetic acid, 2-[(4-chlorophenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, 2-[(4-chlorophenyl)thio]-(13459-62-6)
• EPA Substance Registry System: Benzeneacetic acid, 2-[(4-chlorophenyl)thio]-(13459-62-6)

Safety Data

• Hazardous Substances Data: 13459-62-6(Hazardous Substances Data)

Usage

General Description

Benzeneacetic acid, 2-[(4-chlorophenyl)thio]-, also known as 4-chlorothiophenylacetic acid, is a chemical compound with the molecular formula C10H9ClOS. It is a white powder with a molecular weight of 222.7 g/mol. Benzeneacetic acid, 2-[(4-chlorophenyl)thio]- is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential anti-inflammatory and analgesic properties. In addition, it has been identified as a potential metabolite of certain pesticides and herbicides. Due to its potential uses and importance in various chemical processes, benzeneacetic acid, 2-[(4-chlorophenyl)thio]- is an important compound in the field of organic chemistry.

Upstream product

• 18698-97-0 ortho-bromophenylacetic acid 
• 106-54-7 p-Chlorothiophenol 
• 6469-86-9 2-<4-Chlor-phenylthio>-benzoesaeurechlorid 
• 18698-96-9 o-iodophenylacetic acid 
• 41932-35-8 1-[2-(4-chloro-phenylsulfanyl)-phenyl]-ethanone 

Downstream Products

• 53732-55-1 Aethyl-<2-(p-chlorphenylthio)-phenyl>-acetat 
• 23048-89-7 1-(8-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine 
• 22431-21-6 Dehydrochlothepin 
• 13448-22-1 octoclothepin 
• 1469-28-9 3-chloro-6H-benzo[b][1]benzothiepin-5-one 

Relevant articles and documents

Synthesis and pharmacological properties of 8-chloro-10-(2-dimethylamino-ethoxy)dibenzo[b,f]thiepin and related compounds. Neurotropic and psychotropic agents. III

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Overcoming chloroquine resistance in malaria: Design, synthesis and structure-activity relationships of novel chemoreversal agents

Malaria remains a significant infectious disease with even artemisinin-based therapies now facing resistance in the field. Development of new therapies is urgently needed, either by finding new compounds with unique modes of action, or by reversing resistance towards known drugs with 'chemosensitizers' or 'chemoreversal' agents (CRA). Concerning the latter, we have focused on the resistance mechanisms developed against chloroquine (CQ). We have synthesized a series of compounds related to previously identified CRAs, and found promising novel compounds. These compounds show encouraging results in a coumarin labeled chloroquine uptake assay, exhibiting a dose response in resensitising parasites to the antimalarial effects of chloroquine. Selected compounds show consistent potency across a panel of chloroquine and artemisinin sensitive and resistant parasites, and a wide therapeutic window. This data supports further study of CRAs in the treatment of malaria and, ultimately, their use in chloroquine-based combination therapies.

Fluorinated tricyclic neuroleptics with prolonged effects; some new 8-chloro-3-fluoro-10-piperazino-10,11-dihydrodibenzo[b,f]thiepins

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