1345960-02-2

Basic information

• Product Name: 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile
• Synonyms: 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile
• CAS NO: 1345960-02-2
• Molecular Weight: 343.357
• Mol File: 1345960-02-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile(1345960-02-2)
• EPA Substance Registry System: 2-(1-{[2,2-difluorocyclopropyl]methyl}-2-oxo-1,2-dihydro[1,3]thiazolo[5,4-b]pyridin-5-yl)benzonitrile(1345960-02-2)

Safety Data

• Hazardous Substances Data: 1345960-02-2(Hazardous Substances Data)

Upstream product

• 1345961-01-4 5-chloro-1-[(2,2-difluorocyclopropyl)methyl][1,3]thiazolo[5,4-b]pyridin-2(1H)-one 
• 138642-62-3 2-Cyanophenylboronic acid 
• 62476-56-6 3-amino-2,6-dichloropyridine 
• 108310-81-2 5-chloro-2-methylsulfanyl-thiazolo[5,4-b]pyridine 
• 1345961-00-3 5-chloro-2-methoxy[1,3]thiazolo[5,4-b]pyridine 
• 121879-69-4 5-chloro-1H-thiazolo[5,4-b]pyridin-2-one 

Relevant articles and documents

SUBSTITUTED 1,3-BENZOTHIAZOL-2(3H)-ONES AND [1,3]THIAZOLO[5,4-B]PYRIDIN-2(1H)-ONES AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2

The present invention is directed to benzothiazol-one and thiazolo pyridine-one derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.