13461-01-3 Usage
Description
Aceprometazine, also known as a phenothiazine derivative, is a compound characterized by an acetyl group at the 2-position and a 2-(dimethylamino)-1-propyl group at the 10-position. It is recognized for its pharmaceutical applications and is particularly noted for its calming and sedative effects.
Uses
Used in Pharmaceutical Industry:
Aceprometazine is used as a sedative and antipsychotic agent for the treatment of various conditions, including anxiety, agitation, and sleep disorders. Its calming effects make it a valuable component in the management of these health issues.
Used in Sleep Disorder Treatment:
Aceprometazine is used in combination with Meprobamate (M227750) for the treatment of sleep disorders. The synergistic effect of these two compounds aids in improving sleep quality and duration, providing relief to individuals suffering from insomnia and other sleep-related problems.
Originator
Aceprometazine ,ZYF Pharm Chemical
Manufacturing Process
In a 1 liter flask, equipped with stirrer, thermometer and nitrogen inlet, 241.0
g of 2-acetylphenothiazine (1 mole) is dissolved in 300 ml of dry
dimethylformamide. When the 2-acetylphenothiazine is almost completely
soluble, to this solution is added 275 ml of a 4 N solution of 1-dimethylamino-
2-chloropropane in toluene.The mixture is heated to 50°C and 26.0 g (1.08 moles) of sodium hydride is
added portion-wise, maintaining the temperature at 50°-60°C. The addition
should take about 1 h. The reaction is allowed to stir for 3 h at 50°-60°C. Any
excess hydride is destroyed by the cautious addition of 10 ml methanol, and
the reaction mix is poured into 800 ml of 20% acetic acid.
The toluene layer is separated and extracted with 150 ml of 20% acetic acid,
and discarded. The acid solutions are combined and washed once with
toluene. The toluene is discarded. Fresh toluene (200 ml) is added and caustic
solution is added with cooling and stirring until the pH is 9 or above. The
toluene layer is separated. The aqueous layer is extracted once more with 75
ml of toluene and discarded. The toluene extracts are combined, given a small
water wash, and concentrated. The residue is distilled yielding 10-[2-
(dimethylamino)propyl]-2-acetylphenothiazine.
Therapeutic Function
Neuroleptic, Antitussive
Safety Profile
Poison by subcutaneous route.Moderately toxic by ingestion. A flammable liquid. Whenheated to decomposition it emits toxic vapors of NOx andSOx.
Check Digit Verification of cas no
The CAS Registry Mumber 13461-01-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,6 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 13461-01:
(7*1)+(6*3)+(5*4)+(4*6)+(3*1)+(2*0)+(1*1)=73
73 % 10 = 3
So 13461-01-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H22N2OS/c1-13(20(3)4)12-21-16-7-5-6-8-18(16)23-19-10-9-15(14(2)22)11-17(19)21/h5-11,13H,12H2,1-4H3
