134612-84-3 Usage
Description
4'-Chloro-3,4-dihydroxybenzophenone is an organic compound characterized by its benzophenone structure, featuring a chlorine atom at the 4' position and two hydroxyl groups at the 3 and 4 positions. This molecule exhibits unique chemical properties due to its functional groups and structural configuration, making it a versatile compound for various applications.
Uses
Used in Pharmaceutical Industry:
4'-Chloro-3,4-dihydroxybenzophenone is used as a pharmaceutical compound for its inhibitory activity against protein tyrosine kinase. This activity is significant in the context of various diseases, including cancer, where protein tyrosine kinase plays a crucial role in cell signaling and proliferation. By inhibiting this enzyme, 4'-Chloro-3,4-dihydroxybenzophenone can potentially contribute to the development of novel therapeutic strategies for treating such conditions.
Used in Chemical Research:
In the field of chemical research, 4'-Chloro-3,4-dihydroxybenzophenone serves as a valuable compound for studying structure-activity relationships. Its unique structure allows researchers to investigate the effects of specific functional groups on the compound's biological activity, which can lead to the discovery of new drugs or the optimization of existing ones.
Used in Material Science:
4'-Chloro-3,4-dihydroxybenzophenone may also find applications in material science, particularly in the development of new materials with specific properties. Its chemical structure can be exploited to create novel polymers, coatings, or other materials with tailored characteristics for various industrial applications.
Preparation
preparation by demethylation of 4′-chloro-4-hydroxy-3-methoxybenzophenone with hydrobromic acid in refluxing aqueous acetic acid.
Check Digit Verification of cas no
The CAS Registry Mumber 134612-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,6,1 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134612-84:
(8*1)+(7*3)+(6*4)+(5*6)+(4*1)+(3*2)+(2*8)+(1*4)=113
113 % 10 = 3
So 134612-84-3 is a valid CAS Registry Number.
134612-84-3Relevant articles and documents
Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents
Zhao, Wanyi,Feng, Xiue,Ban, Shurong,Lin, Wenhan,Li, Qingshan
supporting information; experimental part, p. 4132 - 4134 (2010/08/20)
A series of new bromophenols and chlorophenols were prepared by a practical route. The in vitro antioxidative activity of the halophenols was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, and their cytoprotective activity was also tested on hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells (HUVEC). All halophenols tested displayed moderate to good DPPH radical-scavenging activity, and two bromophenols, 2,3′-dibromo-4,5,6′-trihydroxydiphenylmethanone (16c) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone (17c) exhibited high protective activity against H2O2-induced injury in HUVEC with EC50 values of 0.4 and 0.8 μM, respectively. The preliminary structure-activity relationships of these compounds were also investigated in order to determine the essential structures required for their bioactivities.