1346555-34-7

Basic information

• Product Name: 4-(cyclopropylamino)cyclohexanol
• Synonyms: 4-(cyclopropylamino)cyclohexanol
• CAS NO: 1346555-34-7
• Molecular Weight: 155.24
• Mol File: 1346555-34-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(cyclopropylamino)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(cyclopropylamino)cyclohexanol(1346555-34-7)
• EPA Substance Registry System: 4-(cyclopropylamino)cyclohexanol(1346555-34-7)

Safety Data

• Hazardous Substances Data: 1346555-34-7(Hazardous Substances Data)

Upstream product

• 22428-87-1 4,4-ethylenedioxycyclohexan-1-ol 
• 765-30-0 Cyclopropylamine 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 13482-22-9 4-hydroxycyclohexanone 

Downstream Products

• 1346555-35-8 N-cyclopropyl-N-((E)-4-hydroxycyclohexyl)-6-(piperidin-1-yl)picolinamide 
• 1346554-36-6 N-cyclopropyl-N-((Z)-4-hydroxycyclohexyl)-6-(piperidin-1-yl)picolinamide 

Relevant articles and documents

Synthesis and biological evaluation of picolinamides as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)

Synthesis of a series of 6-substituted picolinamide derivatives and their inhibitory activities against 11β-hydroxysteroid dehydrogenase type 1 are described. Optimization of the initial hit compound, N-cyclohexyl-6-(piperidin-1-yl)picolinamide (1) from high throughput screening of in-house library resulted in the discovery of the highly potent and metabolically stable compound 25, which was efficacious in a mouse ex vivo pharmacodynamic model and reduced the fasting blood glucose and insulin levels in a HF/STZ mouse model after oral dosing.