13466-31-4Relevant articles and documents
TEMPO-mediated Aza-diels-alder reaction: Synthesis of tetrahydropyridazines using ketohydrazones and olefins
Yang, Xiu-Long,Peng, Xie-Xue,Chen, Fei,Han, Bing
supporting information, p. 2070 - 2073 (2016/06/09)
A novel, facile, and efficient method for the synthesis of tetrahydropyridazines by a one-pot tandem reaction of easily accessible ketohydrazones and olefins in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) has been successfully developed. The reaction involves the initial generation of azoalkenes from direct oxidative dehydrogenation of ketohydrazones using TEMPO as the commercially available oxidant, followed by a subsequent aza-Diels-Alder reaction with olefins.
Synthesis of a new class of bis(thiourea)hydrazide pseudopeptides as potential inhibitors of β-sheet aggregation
Klein, Jan J.,Hecht, Stefan
supporting information; experimental part, p. 330 - 333 (2012/02/04)
The modular synthesis of a novel pseudopeptide scaffold based on a bis(thiourea)hydrazide motif is reported. This compound class is designed to display "amphifinity", i.e. association with a peptide strand on one but not the other face of the scaffold, and hence could potentially inhibit β-sheet aggregation.
Rh(I) and Ir(I) catalysed intermolecular hydroamination with substituted hydrazines
Dabb, Serin L.,Messerle, Barbara A.
supporting information; experimental part, p. 6368 - 6371 (2009/02/08)
The catalysed intermolecular hydroamination of a series of terminal alkynes with substituted hydrazines was achieved using Rh(i) and Ir(i) complexes.