1346617-84-2

Basic information

• Product Name: N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine
• Synonyms: N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine
• CAS NO: 1346617-84-2
• Molecular Weight: 303.326
• Mol File: 1346617-84-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine(1346617-84-2)
• EPA Substance Registry System: N-(5-azido-2-methylphenyl)-4-(pyridine-3-yl)pyrimidin-2-amine(1346617-84-2)

Safety Data

• Hazardous Substances Data: 1346617-84-2(Hazardous Substances Data)

Upstream product

• 152460-10-1 6-methyl-1-N-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine 
• 66521-66-2 4-pyridin-3-ylpyrimidin-2-ylamine 
• 7745-93-9 2-bromo-4-nitrotoluene 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 1346617-86-4 N-[2-methyl-5-(4-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-1,2,3-triazol-1-yl)phenyl]-4-(pyridine-3-yl)pyrimidin-2-amine 
• 1441640-67-0 (2-methyl-5-{4-(hydroxyethyl)-1,2,3-triazol-1-yl}phenyl)(4-pyridin-3-ylpyrimidin-2-yl)amine 
• 1441640-66-9 (2-methyl-5-{4-[4-methoxyphenyl]-1,2,3-triazol-1-yl}phenyl)(4-pyridin-3-ylpyrimidin-2-yl)amine 
• 1441640-65-8 (2-methyl-5-{4-[3,4-dimethoxyphenyl]-1,2,3-triazol-1-yl}phenyl)(4-pyridin-3-ylpyrimidin-2-yl)amine 
• 1441640-64-7 (2-methyl-5-{4-(2-naphthyl)-1,2,3-triazol-1-yl}phenyl)(4-pyridin-3-ylpyrimidin-2-yl)amine 

Relevant articles and documents

N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the synthesis of inhibitors of Bcr-Abl

N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized and evaluated invitro for their potential use as inhibitors of Bcr-Abl. The design is based on the bioisosterism between the 1,2,3-triazole ring and the amide group. The synthesis involves a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key step, with the exclusive production of anti-(1,4)-triazole derivatives. One of the compounds obtained shows general activity similar to that of imatinib; in particular, it was observed to be more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line. Willing and Abl inhibitors! N-[2-Methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine derivatives were synthesized by a copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as a key step, with anti-(1,4)-triazole derivatives as the exclusive products. One of these compounds shows general activity similar to that of imatinib, and in particular, it is more effective in decreasing the fundamental function of cdc25A phosphatases in the K-562 cell line.

Heterocycle compound containing triazole, as well as preparation method and application of heterocycle compound

The invention provides a heterocycle compound containing triazole, as well as a preparation method and application of the heterocycle compound. The heterocycle compound containing the triazole has a general formula in the following structure (as shown in

Safe and highly efficient syntheses of triazole drugs using Cu2O nanoparticle in aqueous solutions

Triazole moiety is frequently employed in drug discovery and optimization. However, most syntheses of triazole drugs involve isolation of highly explosive azides. Herein we report safe and high efficient syntheses of triazole drugs in aqueous/organic solvent systems with Cu2O nanoparticle (Cu 2O-NP) as the catalyst of azide-alkyne cycloaddition (CuAAC). Since Cu2O-NP can be efficiently dispensed in aqueous and some organic solvents, the azide solutions from the previous preparation could be used directly in the next CuAAC stage without isolation. Therefore, this synthetic strategy is safe, convenient, and high yielding for the syntheses of triazole drugs.