1346758-67-5

Basic information

• Product Name: (S,S)-1,7,7-trimethyl-2,5-diphenylbicyclo[2.2.1]hepta-2,5-diene
• Synonyms: (S,S)-1,7,7-trimethyl-2,5-diphenylbicyclo[2.2.1]hepta-2,5-diene
• CAS NO: 1346758-67-5
• Molecular Weight: 286.417
• Mol File: 1346758-67-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S,S)-1,7,7-trimethyl-2,5-diphenylbicyclo[2.2.1]hepta-2,5-diene(CAS DataBase Reference)
• NIST Chemistry Reference: (S,S)-1,7,7-trimethyl-2,5-diphenylbicyclo[2.2.1]hepta-2,5-diene(1346758-67-5)
• EPA Substance Registry System: (S,S)-1,7,7-trimethyl-2,5-diphenylbicyclo[2.2.1]hepta-2,5-diene(1346758-67-5)

Safety Data

• Hazardous Substances Data: 1346758-67-5(Hazardous Substances Data)

Upstream product

• 5655-61-8 bornyl acetate 
• 2758-63-6 (1S,4S)-1,7,7-trimethylbicyclo[2.2.1]heptane-2,5-dione 
• 1346758-66-4 1,7,7-trimethylbicyclo[2.2.1]hepta-2,5-diene-2,5-diyl bis(trifluoromethanesulfonate) 
• 98-80-6 phenylboronic acid 

Relevant articles and documents

Methods for preparation of apremilast

The present invention discloses a method for preparation of Apremilast. β-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.

Expanding the C1-symmetric bicyclo[2.2.1]heptadiene ligand family: Highly enantioselective synthesis of cyclic β-aryl-substituted carbonyl compounds

The efficient preparation of highly enantioenriched cyclic β-aryl-substituted carbonyl compounds has been achieved through the Rh I-catalyzed asymmetric 1,4-addition of an array of arylboronic acids to cyclic α,β-unsaturated carbonyl compounds. In the presence of 0.1 or 0.5 mol-% of the RhI/1g complex, the products of conjugate addition were isolated in 89 to 98%ee and in good to excellent yield.