134749-45-4

Basic information

• Product Name: 2-Piperazinecarboxylic acid, 1-(phenylmethyl)-, ethyl ester
• CAS NO: 134749-45-4
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.325
• Mol File: 134749-45-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Piperazinecarboxylic acid, 1-(phenylmethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperazinecarboxylic acid, 1-(phenylmethyl)-, ethyl ester(134749-45-4)
• EPA Substance Registry System: 2-Piperazinecarboxylic acid, 1-(phenylmethyl)-, ethyl ester(134749-45-4)

Safety Data

• Hazardous Substances Data: 134749-45-4(Hazardous Substances Data)

Upstream product

• 3674-13-3 2,3-dibromopropionic acid ethyl ester 
• 140-28-3 N,N'-Dibenzylethylenediamine 
• 644-33-7 N,N'-ethanediyl-bis-benzamide 
• 162510-56-7 1-tritylpiperazin-3yl-carboxylic acid ethyl ester 
• 129798-91-0 ethyl piperazine-2-carboxylate dihydrochloride 
• 604785-27-5 1-Benzyl-4-trityl-piperazine-2-carboxylic acid ethyl ester 
• 72351-59-8 ethyl 1,4-dibenzylpiperazin-2-carboxylate 

Downstream Products

• 842135-90-4 1-benzyl-4-(isoquinoline-5-sulfonyl)piperazine-2-carboxylic acid ethyl ester 
• 1308380-88-2 ((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-5-[3-hydroxymethyl-4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester 
• 1308380-87-1 {(R)-2-[3-(2-fluoro-6-trifluoromethyl-benzyl)-5-(3-hydroxymethyl-piperazin-1-yl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 1308380-86-0 {(R)-2-[5-(4-benzyl-3-hydroxymethyl-piperazin-1-yl)-3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 1308379-84-1 3-((R)-2-amino-2-phenyl-ethyl)-1-(2-fluoro-6-trifluoromethyl-benzyl)-5-[3-hydroxymethyl-4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-6-methyl-1H-pyrimidine-2,4-dione 
• 476493-27-3 (1-benzyl-piperazin-2-yl)-methanol 
• 1118969-32-6 1-benzyl-4-(3-methoxy-benzenesulfonyl)-piperazine-2-carboxylic acid ethyl ester 
• 63285-62-1 2-methyloctahydro-2H-pyrazino[1,2-a]pyrazine 
• 134749-51-2 2-benzyl-8-(trifluoromethylsulfonyl)octahydropyrazino<1,2-a>pyrazine-1,4-dione 
• 134749-52-3 2-Benzyl-octahydro-pyrazino[1,2-a]pyrazine 
• 4744-60-9 octahydro-2H-pyrazino<1,2-a>pyrazin 
• 842135-93-7 5-[4-benzyl-3-(4-chlorobenzyloxymethyl)-piperazine-1-sulfonyl]-isoquinoline 
• 842135-92-6 [1-benzyl-4-(isoquinoline-5-sulfonyl)piperazin-2-yl]-methanol 
• 229647-15-8 4-[(chloro-2-naphthalenyl)sulfonyl]-1-(phenylmethyl)-2-piperazinecarboxylic acid ethyl ester 

Relevant articles and documents

DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS

Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.

PIPERAZINE AMIDE DERIVATIVES

The invention is concerned with novel piperazine amide derivatives of formula (I) wherein R1 to R11, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.

AROMATIC COMPOUNDS HAVING CYCLIC AMINO OR SALTS THEREOF

Compounds represented by general formula (I) or salts thereof which specifically inhibit FXa, exert a potent anticoagulant effect and thus are useful as medicinal compositions, wherein G1 to G4, X and Y represent each CH or N; Z1 represents -SO2- or -CH2 -; Q represents aryl or heteroaryl; and R1 to R9 represent each hydrogen or a substituent.