1347537-78-3

Basic information

• Product Name: Nε-feruloyl-S-(6-purinyl)-L-thiolysine
• Synonyms: Nε-feruloyl-S-(6-purinyl)-L-thiolysine
• CAS NO: 1347537-78-3
• Molecular Weight: 471.54
• Mol File: 1347537-78-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Nε-feruloyl-S-(6-purinyl)-L-thiolysine(CAS DataBase Reference)
• NIST Chemistry Reference: Nε-feruloyl-S-(6-purinyl)-L-thiolysine(1347537-78-3)
• EPA Substance Registry System: Nε-feruloyl-S-(6-purinyl)-L-thiolysine(1347537-78-3)

Safety Data

• Hazardous Substances Data: 1347537-78-3(Hazardous Substances Data)

Upstream product

• 1253696-85-3 C₁₆H₂₂N₂O₅ 
• 154985-75-8 6-thioguanine 

Relevant articles and documents

Synthesis of pro-prodrugs l-lysine based for 5-aminosalicylic acid and 6-mercaptopurine colon specific release

The aim of this work is to design, prepare and characterize l-lysine based prodrugs capable of targeting 6-mercaptopurine to the colon, an anti-tumor and immunosuppressant drug, and 5-aminosalicylic acid (5-ASA), drug of choice for inflammatory bowel disease (IBD). More specifically, Nε-feruloyl-S-(6- purinyl)-l-lysine and Nε-acryloyl-S-(6-purinyl)-l-lysine were synthesized and then characterized by FT-IR, 1H-NMR and GC/MS spectroscopies. The ability of feruloyl derivative in inhibiting lipid peroxidation in rat liver microsomal membranes, induced in vitro by tert-butyl hydroperoxide as source of free radicals, was evaluated. Moreover, Nε-acryloyl-S-(6-purinyl)-l-lysine, polymerizable prodrug, was used to microspheres realization for 5-ASA release. These lasts, obtained by emulsion inverse technique, were characterized by light scattering and scanning electron microscopy (SEM) analysis. The microspheres equilibrium swelling degree was evaluated and showed good swelling behaviour in simulating colonic fluids. Results confirm the possibility that the application range of l-lysine prodrug can be extended to the treatment of intestinal diseases whose conventional therapy envisages medications with serious side effects that, thanks to this new strategy, can be minimized in an optimal way.