134782-13-1Relevant articles and documents
Preparation of the pyridinium salts differing in the length of the N-alkyl substituent
Marek, Jan,Stodulka, Petr,Cabal, Jiri,Soukup, Ondrej,Pohanka, Miroslav,Korabecny, Jan,Musilek, Kamil,Kuca, Kamil
experimental part, p. 1967 - 1972 (2010/09/08)
Quaternary pyridinium salts with chains ranging from C8 to C20 belong in the large group of cationic surfactants. In this paper, the preparation of such cationic surface active agents based on the pyridinium moiety and differing in the length of the N-alkyl chain is described. Additionally, HPLC technique was established to distinguish each prepared pyridinium analogue. This study represents universal method for preparation and identification of quaternary pyridinium detergents.
BIS-PYRIDINO CONTAINING COMPOUNDS FOR USE IN THE TREATMENT OF CNS PATHOLOGIES
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Page/Page column 38-39, (2008/06/13)
N-n-Alkylation of nicotine converts nicotine from an agonist into an antagonist specifically for neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogs exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.