134861-13-5

Basic information

• Product Name: H2S Donor 5a
• Synonyms: H2S Donor 5a;N-(Benzoylthio)benzamide
• CAS NO: 134861-13-5
• Molecular Formula: C₁₄H₁₁NO₂S
• Molecular Weight: 257.30764
• Mol File: 134861-13-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 138-140℃ (dichloromethane hexane )
• Appearance: /
• Density: 1.266±0.06 g/cm3(Predicted)
• PKA: 8.97±0.46(Predicted)
• CAS DataBase Reference: H2S Donor 5a(CAS DataBase Reference)
• NIST Chemistry Reference: H2S Donor 5a(134861-13-5)
• EPA Substance Registry System: H2S Donor 5a(134861-13-5)

Safety Data

• Hazardous Substances Data: 134861-13-5(Hazardous Substances Data)

Usage

Description

H2S Donor 5a is a stable, cysteine-activated hydrogen sulfide (H2S) donor that is capable of releasing H2S in the presence of an excess of cysteine. H2S Donor 5a has a unique property of not reacting with potential cellular nucleophiles such as -OH and -NH2 groups, which makes it a promising candidate for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
H2S Donor 5a is used as a therapeutic agent for various medical applications due to its ability to release hydrogen sulfide in a controlled manner. The controlled release of H2S can have potential benefits in treating conditions such as inflammation, hypertension, and other diseases where H2S has been shown to play a role.
Used in Research Applications:
H2S Donor 5a is used as a research tool for studying the biological effects of hydrogen sulfide. Its stable nature and specificity for cysteine activation make it an ideal compound for investigating the role of H2S in various cellular processes and signaling pathways.
Used in Drug Delivery Systems:
H2S Donor 5a can be employed in the development of novel drug delivery systems to improve the targeted delivery of H2S to specific cells or tissues. This could potentially enhance the therapeutic effects of H2S and minimize any potential side effects associated with its release.

Upstream product

• 25740-80-1 S-benzoylthiohydroxylamine 
• 93-97-0 benzoic acid anhydride 
• 98-91-9 thiobenzoic acid 

Downstream Products

• 7783-06-4 hydrogen sulfide 
• 7217-84-7 2-benzamido-3-mercaptopropanoic acid 
• 55-21-0 benzamide 
• 6199-20-8 cysteine hydropersulfide 
• 56-89-3 L-cystine 

Relevant articles and documents

Hydrogen sulfide donor based on keratin as well as synthesis method and application thereof

The invention discloses a hydrogen sulfide donor based on keratin as well as a synthesis method and application thereof. The synthesis method comprises the following steps: dissolving keratin in a buffer solution, adding an activating agent, and performing reaction to obtain a solution A; dissolving a small molecular hydrogen sulfide donor into an organic solvent, then adding the organic solvent into the solution A, and continuing reaction to obtain a reaction solution B; dialyzing the reaction solution B, and carrying out freeze-drying to obtain the hydrogen sulfide donor based on keratin. The synthesized hydrogen sulfide based on keratin has good water solubility, and the problem that hydrogen sulfide is difficult to dissolve in a water environment is solved. By adopting the keratin macromolecular donor, the hydrogen sulfide release time is prolonged, and the problem that the micromolecular donor is released too fast is solved. The synthesis method disclosed by the invention is simple and feasible, non-toxic and low in cost, can be applied to large-scale production, realizes coupling with other materials or molecules, and is beneficial to preparation of a multifunctional hydrogensulfide release composite material.

Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors

Hydrogen sulfide (H2S) is a signaling molecule which plays regulatory roles in many physiological and/or pathological processes. Therefore, regulation of H2S levels could have great potential therapeutic value. In this work, we report the design, synthesis, and evaluation of a class of N-mercapto (N-SH)-based H2S donors. Thirty-three donors were synthesized and tested. Our results indicated that controllable H2S release from these donors could be achieved upon structural modifications. Selected donors (NSHD-1, NSHD-2, and NSHD-6) were tested in cellular models of oxidative damage and showed significant cytoprotective effects. Moreover, NSHD-1 and NSHD-2 were also found to exhibit potent protective effects in a murine model of myocardial ischemia reperfusion (MI/R) injury.