134970-66-4

Basic information

• Product Name: Benzenepropanol, a-[1-chloro-1-[(4-methylphenyl)sulfinyl]ethyl]-
• CAS NO: 134970-66-4
• Molecular Formula: C18H21ClO2S
• Molecular Weight: 336.883
• Mol File: 134970-66-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenepropanol, a-[1-chloro-1-[(4-methylphenyl)sulfinyl]ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, a-[1-chloro-1-[(4-methylphenyl)sulfinyl]ethyl]-(134970-66-4)
• EPA Substance Registry System: Benzenepropanol, a-[1-chloro-1-[(4-methylphenyl)sulfinyl]ethyl]-(134970-66-4)

Safety Data

• Hazardous Substances Data: 134970-66-4(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 50635-71-7 1-chloroethyl p-tolyl sulfoxide 

Downstream Products

• 134970-53-9 N-benzyl-2-hydroxy-4-phenylbutanamide 
• 134970-52-8 N-hexyl-2-hydroxy-4-phenylbutanamide 
• 134970-47-1 pentyl 2-hydroxy-4-phenylbutyrate 
• 134970-54-0 N,N-diethyl-2-hydroxy-4-phenylbutanamide 
• 134970-55-1 N-(2-hydroxy-4-phenylbutanoyl)piperidine 
• 130159-28-3 isopropyl 2-hydroxy-4-phenylbutyrate 
• 109684-03-9 benzyl 2(R)-hydroxy-4-phenylbutyrate 
• 7226-82-6 (RS)-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 4263-93-8 2-hydroxy-4-phenylbutanoic acid 
• 93921-85-8 ethyl 2-hydroxy-4-phenylbutanoate 
• 91012-00-9 2-hydroxy-4-phenylbutanamide 
• 141054-32-2 1-Phenyl-4-(toluene-4-sulfonyl)-pentan-3-one 
• 62692-43-7 2-chloro-5-phenyl-pent-2ξ-ene 
• 141036-83-1 2-chloro-2-(p-tolylsulfonyl)-5-phenyl-3-pentanone 

Relevant articles and documents

Favorskii rearrangement of α-chloro β-keto sulfones with amines: A new synthesis of amides and α,β-unsaturated amides from aldehydes and ketons

The Favorskii rearrangement of α-chloro β-keto sulfones, which are easily synthesized from aldehydes and ketones, with amines gives β-sulfonyl amides in good yield. These β-sulfonyl amides are converted to amides and α,β-unsaturated amides by reduction or elimination of the sulfonyl group.

Favorskii Rearrangement and Carbon-Carbon Bond-Cleavage of α-Chloro-α-sulfonyl Ketones: A Synthesis of Carboxylic Acids and Their Derivatives from Aldehydes and Ketones

A method for synthesizing carboxylic acids and their derivatives from aldehydes and ketones via α-chloro-α-sulfonyl ketones is described.Acyclic α-chloro-α-sulfonyl ketones were synthesized from aldehydes and 1-chloroalkyl p-tolyl sulfoxides with carbon-carbon coupling in good overall yields.Cyclic α-chloro-α-sulfonyl ketones were synthesized from cyclic ketones in three steps in high overall yields.The Favorskii rearrangement of both acyclic and cyclic α-chloro-α-sulfonyl ketones with sodium hydride in the presence of amine gave β-sulfonyl amides with skeletal rearrangement in good to excellent yield.Amides and α,β-unsaturated amides were synthesized from the β-sulfonyl amides.Treatment of the cyclic α-chloro-α-sulfonyl ketones with alkoxides and hydroxide gave carboxylic esters and acids with cleavage of the ring in good to excellent yields.

A NOVEL SYNTHESIS OF HALOALKENES FROM ALDEHYDES WITH CARBON-CARBON COUPLING

Treatment of α-halo β-mesyloxy sulfoxides, easily synthesized from aldehydes and 1-haloalkyl aryl sulfoxides in two steps, with n-BuLi at -78 deg C gives haloalkenes in good yields. Key words: Sulfoxide; 1-haloalkyl aryl sulfoxide; fluoroalkene; chloroalk