134978-99-7Relevant articles and documents
Spacer molecules in peptide sequences: Incorporation into analogues of atrial natriuretic factor
Boumrah, Deradji,Campbell, Malcolm M.,Fenner, Simon,Kinsman, Richard G.
, p. 7735 - 7738 (1991)
The spacer reagents FmocHN(CH2CH2CH2)3CH 2COOPfp (1b) and FmocHN(CH2CH2O) 3CH2COOPfp (2d) have been prepared and used to substitute for tetra-residue sequences in the cyclic portion of Atrial Natriuretic Factor (ANF) by solid phase peptide assembly.
Synthesis of a polymerizable metal-ion-chelating lipid for fluid bilayers
Sang Won Jeong,O'Brien
, p. 4799 - 4802 (2001)
Hydrated lipid structures, such as liposomes, that display tethered metal-ion-chelating groups have proven useful in peptide and protein binding, as well as 2D protein crystallization through molecular recognition of accessible histidine sites in proteins and peptides. Polymerizable metal-ion-chelating lipids bearing a reactive diacetylene group have been described. These interesting compounds can be polymerized in the solid-analogous phase. Here we describe the design of the first polymerizable metal-ion-chelating lipid that can be used in the fluid, i.e., liquid analogous, phase of lipid bilayers. The synthesis of 1-palmitoyl-2-[8-[(E,E)-2′,4′-hexadienoyloxy] octanoyl]-sn-glycero-3-N-[11-[N′,N′bis- [carboxymethyl]imino]-3,6,9-trioxaundecanoyl] phosphatidylethanolamine (1) is described. The chelator moiety, iminodiacetate (IDA), was linked to the polymerizable phosphatidylethanolamine (PE) with a terminal 2,4-hexadienoyl (sorbyl) group through an oligo(ethylene glycol)-based spacer. Lipid 1-Cu complex is designed to be combined with the corresponding polymerizable matrix lipids (bis-SorbPC) to form functionalized liposomes that can be stabilized by various polymerization methods.
Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase
Shi, Haibin,Liu, Kai,Xu, Ashley,Yao, Shao Q.
supporting information; experimental part, p. 5030 - 5032 (2010/01/06)
A small molecule microarray (SMM) platform is developed herein, which enables high-throughput discovery of affinity-based probes (AfBPs) against γ-secretase.
Membrane activation: Selective vesicle fusion via small molecule recognition
Gong, Yun,Luo, Yumei,Bong, Dennis
, p. 14430 - 14431 (2008/01/27)
We report herein the induction of selective vesicle fusion with biological recognition motifs not natively associated with lipid bilayer fusion, thus broadening the scope of recognition-guided membrane activation. Our system employs vancomycin glycopeptid
