1349902-81-3

Basic information

• Product Name: C₂₇H₃₁F₇N₄O₄
• Synonyms: C₂₇H₃₁F₇N₄O₄
• CAS NO: 1349902-81-3
• Molecular Weight: 608.556
• Mol File: 1349902-81-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₃₁F₇N₄O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₃₁F₇N₄O₄(1349902-81-3)
• EPA Substance Registry System: C₂₇H₃₁F₇N₄O₄(1349902-81-3)

Safety Data

• Hazardous Substances Data: 1349902-81-3(Hazardous Substances Data)

Upstream product

• 155764-79-7 C₇H₁₄ClN₃O₂ 
• 171482-05-6 [2R-[2α(R*),3α]]-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride 

Downstream Products

• 170729-80-3 aprepitant 

Relevant articles and documents

PREPARATION METHOD OF 5-[[2(R)-[1(R)-[3,5-BIS(TRIFLUOROMETHYL) PHENYL]ETHOXY]-3(S)-4-FLUOROPHENYL-4-MORPHOLINYL]METHYL]-1,2-DIHYDRO-3H-1,2,4-TRIAZOLE-3-ONE

Disclosed is a synthesis method of a compound of formula 1,5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxyl]-3(S)-4-fluorophenyl-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one (i.e. aprepitant), which comprises cyclizing a compound of formula 4 in a solvent, wherein R is C1-C5 alkyl. The intermediate for preparing aprepitant is also disclosed. The present method is especially suitable for industrial production of aprepitant.