135041-03-1Relevant articles and documents
Control of stereoselectivity in samarium metal induced cyclopropanations. Synthesis of 1,25-Dihydroxycholecalciferol
Kabat,Kiegiel,Cohen,Toth,Wovkulich,Uskokovic
, p. 2343 - 2346 (1991)
1,25-Dihydroxycholecalciferol (23) was synthesized from A-ring precursor 18 and Windaus-Grundmann ketone 19 via cyclovitamin D 21. Key reactions include highly stereoselective (5 to 6) and stereospecific (13 to 14) cyclopropanations.