1350737-69-7

Basic information

• Product Name: 4-(4-methoxyphenyl)-2-phenylpyridine
• Synonyms: 4-(4-methoxyphenyl)-2-phenylpyridine
• CAS NO: 1350737-69-7
• Molecular Weight: 261.323
• Mol File: 1350737-69-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 4-(4-methoxyphenyl)-2-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-methoxyphenyl)-2-phenylpyridine(1350737-69-7)
• EPA Substance Registry System: 4-(4-methoxyphenyl)-2-phenylpyridine(1350737-69-7)

Safety Data

• Hazardous Substances Data: 1350737-69-7(Hazardous Substances Data)

Upstream product

• 696-62-8 para-iodoanisole 
• 613-91-2 acetophenone oxime 
• 98-86-2 acetophenone 
• 959-33-1 3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one 
• 5938-16-9 4-(4-methoxylphenyl)pyridine 
• 591-51-5 phenyllithium 
• 59954-73-3 4-(4-methoxyphenyl)-1,2,3,6-tetrahydro-pyridine 
• 1963-36-6 4-methoxycinnamaldehyde 
• 19433-17-1 acetophenone O-acetyloxime 
• 18162-28-2 5-phenyl-1,2,4-triazine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1443156-62-4 3-bromo-3-(4-methoxyphenyl)acrylaldehyde 
• 1449578-03-3 C₁₈H₁₆O₂ 
• 19433-17-1 (E)‐1‐phenylethan‐1‐one O‐acetyl oxime 

Relevant articles and documents

Palladium-Catalyzed Electrophilic Functionalization of Pyridine Derivatives through Phosphonium Salts

Herein, we report a highly efficient and practical method for pyridine-derived heterobiaryl synthesis through palladium-catalyzed electrophilic functionalization of easily available pyridine-derived quaternary phosphonium salts. The nice generality of this reaction was goes beyond arylation, enabling facile incorporation of diverse carbon-based fragments, including alkenyl, alkynyl, and also allyl fragments, onto the pyridine core. Notably, the silver salt additive is revealed to be of vital importance for the success of this transformation and its pivotal role as transmetallation mediator, which guarantees a smooth transfer of pyridyl group to palladium intermediate, is also described.

Synthesis of polysubstituted pyridines from oxime acetates using NH4I as a dual-function promoter

Pyridine formation with oxime acetates as the building blocks under metal-free conditions is described. Ammonium iodide has proved to be a highly efficient promoter for oxime N-O bond reduction and subsequent condensation reactions, whereby it played a dual-function role in the transformation. While the three-component reaction of oxime acetates, benzaldehydes, and 1,3-dicarbonyls proceeded well with the assistance of a stoichiometric amount of ammonium iodide, the condensation of oximes and acroleins was enabled by using a catalytic initiator to afford substituted pyridines. By this protocol, substituted pyridine products were generated in moderate to excellent yields with tolerance towards a broad range of functional groups.

The use of organolithium reagents for the synthesis of 4-aryl-2-phenylpyridines and their corresponding iridium(III) complexes

A versatile palladium-free route for the synthesis of 4-aryl-substituted phenylpyridines (ppy), starting from tert-butyl 4-oxopiperidine-1-carboxylate, is reported. Reaction with an aryllithium, followed by trifluoroacetic acid dehydration/deprotection and oxidation with 2-iodoylbenzoic acid and finally phenylation, gave 4 ligands (L1-4H): 2,4-diphenylpyridine, 4-(4-methoxyphenyl)-2-phenylpyridine, 2-phenyl-4-(o-tolyl)pyridine and 4-mesityl-2-phenylpyridine. These ligands were coordinated to iridium to give the corresponding Ir(L)2(A) complexes (Ir1-7), where A = ancillary ligand acetylacetate or 2-picolinate. This was used to demonstrate that, through a combination of ancillary ligand choice and torsional twisting between the 4-aryl substituents of the ppy ligands, it is possible to tune the phosphorescent emission of the complexes in the range 502-560 nm.