13509-13-2

Basic information

• Product Name: 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI)
• Synonyms: 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI);4-Methylpyridine-2-carboxylic acid methyl ester;Methyl 4-Methylpicolinate;2-Pyridinecarboxylicacid, 4-Methyl-, Methyl ester;Methyl 4-methyl-2-picolinate;4-Methylpicolinic acid methyl ester
• CAS NO: 13509-13-2
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.17
• Product Categories: CARBOXYLICESTER;GLYCINESCAFFOLD
• Mol File: 13509-13-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 260.732°C at 760 mmHg
• Flash Point: 111.487°C
• Appearance: /
• Density: 1.105g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 2.52±0.10(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI)(13509-13-2)
• EPA Substance Registry System: 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI)(13509-13-2)

Safety Data

• Hazardous Substances Data: 13509-13-2(Hazardous Substances Data)

Usage

General Description

2-Pyridinecarboxylic acid, 4-methyl-, methyl ester (9CI) is a chemical compound with the molecular formula C8H9NO2. It is a methyl ester derivative of 4-methyl-2-pyridinecarboxylic acid and belongs to the class of pyridinecarboxylic acids. 2-Pyridinecarboxylicacid,4-methyl-,methylester(9CI) is commonly used in the production of pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its anti-inflammatory and antioxidant properties. Additionally, it is used as a building block in the synthesis of various organic compounds. This chemical compound is important in the field of organic chemistry and has a wide range of applications in the pharmaceutical and agricultural industries.

InChI:InChI=1/C8H9NO2/c1-6-3-4-9-7(5-6)8(10)11-2/h3-5H,1-2H3

Upstream product

• 67-56-1 methanol 
• 4021-08-3 4-methylpicolinic acid 
• 186581-53-3 diazomethane 
• 4926-28-7 2-Bromo-4-picoline 
• 124-38-9 carbon dioxide 
• 19854-23-0 2-(Trimethylsilyl)-4-methyl-pyridin 
• 74-88-4 methyl iodide 
• 452-86-8 4-methyl-1,2-dihydroxybenzene 
• 1003-67-4 4-methylpyridine-1-oxide 
• 1620-76-4 2-Cyano-4-methylpyridin 
• 2459-07-6 methyl pyridine-2-carboxylate 
• 108-47-4 2,4-lutidine 

Downstream Products

• 42508-74-7 (4-methyl-2-pyridinyl)methanol 
• 71670-71-8 2-chloromethyl-4-methyl-pyridine-hydrochloride 
• 1571023-14-7 1-{[2-(2-hydroxypropan-2-yl)pyridin-4-yl]methyl}-5-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1,2-dihydropyridin-2-one 
• 317332-32-4 1-(3-benzyl-5-pyrazin-2-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione 
• 317333-21-4 1-(3-benzyl-5-[1,2,4]triazol-1-ylmethylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione 
• 317333-19-0 1-(6-benzyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl)-3-(4-methylpyridin-2-yl)propane-1,3-dione 
• 317332-80-2 1-[3-benzyl-5-(2-oxo-2H-pyridin-1-ylmethyl)phenyl]-3-(4-methylpyridin-2-yl)-propane-1,3-dione 
• 317332-83-5 1-(3-benzylphenyl)-3-(4-methylpyridin-2-yl)-propane-1,3-dione 
• 317335-16-3 methyl 4-(bromomethyl)picolinate 

Relevant articles and documents

Synthesis of Esters by Functionalisation of CO2

The invention relates to a method for (I) producing a carboxylic ester of formula (I). Said method comprises the steps of: a) bringing an organosilane/borane of formula Si or B into contact with CO2, in the presence of a catalyst and an electrophilic compound of formula (III), the groups R1, R2, R3, R4, R5, Y, and M′ being as defined in claim 1; and optionally b) recovering the compound of formula (I) produced.

Development of an iron(II)-catalyzed aerobic catechol cleavage and biomimetic synthesis of betanidin

An aerobic iron(II)-catalyzed cleavage of catechols was developed. This reaction allows for the preparation of 2-methoxy-2H-pyrans that can be employed as versatile building blocks for synthesis. The utility of this biomimetic oxidative cleavage is featured in the synthesis of betanidin, a natural colorant with antioxidant properties. Cut and paste: An aerobic iron(II)-catalyzed oxidative cleavage of catechol was developed. This reaction allows the preparation of 2H-pyrans that can be employed as versatile building blocks for synthesis. The utility of this biomimetic cleavage is featured in the synthesis of betanidin, the aglycone of red beets' principal colorant and itself a valuable antioxidant (see scheme).

1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof

Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.