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1350925-22-2

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1350925-22-2 Usage

General Description

3,6-dichloropyrido[2,3-b]pyrazine is a chemical compound that contains two chlorine atoms. It is a heterocyclic aromatic compound with a pyridine and pyrazine ring fused together. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Due to its unique structure, 3,6-dichloropyrido[2,3-b]pyrazine exhibits diverse biological activities, making it an important intermediate in the production of various drugs and pesticides. It is important to handle this compound with care, as exposure to high levels of 3,6-dichloropyrido[2,3-b]pyrazine can be harmful to human health and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 1350925-22-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,0,9,2 and 5 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1350925-22:
(9*1)+(8*3)+(7*5)+(6*0)+(5*9)+(4*2)+(3*5)+(2*2)+(1*2)=142
142 % 10 = 2
So 1350925-22-2 is a valid CAS Registry Number.

1350925-22-2Relevant articles and documents

A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH

Aikawa,Yano,Nakatani

, p. 1313 - 1316 (2017/02/15)

The synthesis and properties of 2,7-diamino-1,4,8-triazanaphthalene (azaDANP) are described. AzaDANP is protonated only at a weakly acidic pH to bind to the cytosine bulge DNA duplex selectively. Upon binding of azaDANP to the cytosine bulge DNA, a new absorption band at 407 nm appears, and the absorption change of azaDANP on binding to the target is very sensitive to environmental pH with a bell-shaped pH-absorption profile.

COMBINATION OF KINASE INHIBITORS AND USES THEREOF

-

, (2015/02/19)

The present invention provides for a method for treating a disease condition associated with PI3-kinase a and/or a receptor tyrosine kinase (RTK) in a subject. In another aspect, the invention provides for a method for treating a disease condition associated with PI3-kinase α and/or an RTK in a subject. In yet another aspect, a method of inhibiting phosphorylation of Akt (S473) in a cell is set forth.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

-

, (2013/06/06)

Heterocyclic entities that modulate PI3 kinase activity, pharmaceutical compositions containing the heterocyclic entities, and methods of using these chemical entities for treating diseases and conditions associated with PI3 kinase activity are described herein.

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