13511-84-7Relevant articles and documents
The importance of agitation and fill volume in small scale scientific microwave reactors
Moseley, Jonathan D.,Lenden, Philip,Thomson, Anthony D.,Gilday, John P.
, p. 6084 - 6087 (2007)
The effect of agitation and fill volume in a microwave tube on the rate of homogenous reaction solutions under both stirred and unstirred conditions is reported. Significant increases in rate are found in two different microwave instruments when the homog
A comparison of commercial microwave reactors for scale-up within process chemistry
Moseley, Jonathan D.,Lenden, Philip,Lockwood, Mark,Ruda, Katinka,Sherlock, Jon-Paul,Thomson, Anthony D.,Gilday, John P.
, p. 30 - 40 (2012/12/31)
Seven commercially available microwave reactors designed for limited scale-up have been investigated using a highly reliable and robust reaction (the Newman-Kwart rearrangement). The use of a single reaction has enabled the comparison to be made across the range of different reactor types and scales. Overall, all reactors gave reliable scale-up from small scale, and performance equivalent to one another on large scale. A more detailed comparison between them is given in the concluding section.
Scaling-out pharmaceutical reactions in an automated stop-flow microwave reactor
Moseley, Jonathan D.,Woodman, Emily K.
, p. 967 - 981 (2013/01/03)
Six pharmaceutically relevant reactions were assessed for scaleout in an automated stop-flow microwave reactor. Daily throughputs of between 50 and 250 g were achieved at typical reaction concentrations; for more concentrated reactions, or with 24 h proce