135129-91-8

Basic information

• Product Name: 3,5-bis(trimethylsilyl)trifluoroacetophenone
• Synonyms: 3,5-bis(trimethylsilyl)trifluoroacetophenone
• CAS NO: 135129-91-8
• Molecular Weight: 318.486
• Mol File: 135129-91-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,5-bis(trimethylsilyl)trifluoroacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-bis(trimethylsilyl)trifluoroacetophenone(135129-91-8)
• EPA Substance Registry System: 3,5-bis(trimethylsilyl)trifluoroacetophenone(135129-91-8)

Safety Data

• Hazardous Substances Data: 135129-91-8(Hazardous Substances Data)

Upstream product

• 2060-89-1 m-bis(trimethylsilyl)benzene 
• 407-25-0 trifluoroacetic anhydride 

Relevant articles and documents

Process research on the preparation of 1-(3-trimethylsilylphenyl)-2,2,2- trifluoroethanone by a friedel-crafts acylation reaction

Zifrosilone (1-(3-trimethylsilylphenyl)-2,2,2-trifluoroethanone) (3) is a Cholinesterase inhibitor that has been studied for the treatment of Alzheimer's disease. Process research has been carried out on a route to convert phenyltrimethylsilane to 3 by Friedel-Crafts acylation using trifluoroacetic anhydride. Kinetics and products analyses suggest that the optimal conditions for this reaction are noncatalytic amounts of aluminum chloride, dichloromethane solvent and as low a temperature as can be practically used in a scaled-up process. Significant separation challenges to isolate 3 from the isomer byproduct 1-(4-trimethykilylphenyl)-2,2,2-trifluoroethanone) (4) remain. These challenges were investigated using vapor-liquid equilibrium studies.