135130-98-2 Usage
Description
Carbamic acid, [(1S)-2-phenyl-1-[(2R)-tetrahydro-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester is a complex organic compound with a unique chemical structure. It is characterized by its carbamic acid functional group and a phenyl-furanylethyl ester moiety. This molecule is known for its potential role in the development of pharmaceuticals and other applications due to its specific structural features.
Uses
Used in Pharmaceutical Industry:
Carbamic acid, [(1S)-2-phenyl-1-[(2R)-tetrahydro-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester is used as an intermediate in the synthesis of γ-Secretase Inhibitor. This inhibitor targets the enzyme complex responsible for the cleavage of amyloid precursor protein (APP) to generate amyloid β-peptide (Aβ), which is a major causative agent in Alzheimer's disease (AD). By inhibiting γ-secretase, this compound can potentially help in the development of treatments for Alzheimer's disease.
Used in Chemical Research:
Due to its unique structure, Carbamic acid, [(1S)-2-phenyl-1-[(2R)-tetrahydro-5-oxo-2-furanyl]ethyl]-, 1,1-dimethylethyl ester can also be used in chemical research for the development of new compounds and materials. Its specific functional groups and structural features make it a valuable starting point for the synthesis of various organic molecules with potential applications in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 135130-98-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,1,3 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 135130-98:
(8*1)+(7*3)+(6*5)+(5*1)+(4*3)+(3*0)+(2*9)+(1*8)=102
102 % 10 = 2
So 135130-98-2 is a valid CAS Registry Number.
135130-98-2Relevant articles and documents
A stereocontrolled synthesis of 2R-benzyl-5S-tert-butoxycarbonylamino-4R-(tert-butyldimethylsilanyloxy)-6- phenyl-hexanoic acid (Phe-Phe hydroxyethylene dipeptide isostere)
Nadin, Alan,Sánchez López, José M,Neduvelil, Joseph G,Thomas, Steven R
, p. 1861 - 1864 (2001)
2R-Benzyl-5S-tert-butoxycarbonylamino-4R-(tert-butyldimethylsilanyloxy)-6- phenyl-hexanoic acid, a hydroxyethylene dipeptide isostere corresponding to Phe-Phe, has been synthesized in a practical, stereocontrolled fashion from (L)-phenylalanine.
Synthesis of a complete series of C-4 fluorinated Phe-Gly mimetics
Berts, Wei,Luthman, Kristina
, p. 13819 - 13830 (2007/10/03)
The complete series of Boc-protected allylic mono- and difluorinated Phe-Gly methyl ester derivatives has been synthesized using facile methods. Diastereomeric allylic alcohol derivatives were used as key intermediates, cis- And trans-aziridine derivative
Peptide inhibitors of aspartic proteinases with hydroxyethylene isostere replacement of peptide bond. I. Preparation of four diastereoisomeric (2R or 2S, 4R or 4S, 5S)-2-benzyl-5-[(tert-butoxycarbonyl)amino]-4-hydroxy-6-phenylhexanoic acids
Litera, Jaroslav,Budesinsky, Milos,Urban, Jan,Soucek, Milan
, p. 231 - 244 (2007/10/03)
By two separate routes were prepared four diastereoisomers of (2R or 2S,5R or 5S)-3-benzyl-5-{(1S)-[(tert-butoxycarbonyl)amino]-2-phenylethyl}tetrahydrofuran- 2-ones (11, 12, 17 and 18). Since the furanones were derived from (S)-phenylalanine, absolute co