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1352078-76-2

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1352078-76-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1352078-76-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,5,2,0,7 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1352078-76:
(9*1)+(8*3)+(7*5)+(6*2)+(5*0)+(4*7)+(3*8)+(2*7)+(1*6)=152
152 % 10 = 2
So 1352078-76-2 is a valid CAS Registry Number.

1352078-76-2Relevant articles and documents

TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE

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Paragraph 1505, (2018/05/24)

The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.

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