1352127-31-1

Basic information

• Product Name: C₂₃H₁₉FN₂O₄
• CAS NO: 1352127-31-1
• Molecular Weight: 406.413
• Mol File: 1352127-31-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₃H₁₉FN₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₁₉FN₂O₄(1352127-31-1)
• EPA Substance Registry System: C₂₃H₁₉FN₂O₄(1352127-31-1)

Safety Data

• Hazardous Substances Data: 1352127-31-1(Hazardous Substances Data)

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 150256-42-1 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)benzoic acid 
• 326901-33-1 ethyl 2-(2-nitrobenzoylamino)-benzoate 
• 228581-79-1 ethyl 2-(2-aminobenzoylamino)-benzoate 
• 393-52-2 2-Fluorobenzoyl chloride 
• 552-16-9 ortho-nitrobenzoic acid 

Downstream Products

• 1352126-73-8 2-[2-(2-fluorobenzoylamino)-benzoylamino]benzoic acid 

Relevant articles and documents

Synthesis, biological evaluation, and structure-activity relationships of 2-[2-(benzoylamino)benzoylamino]benzoic acid analogues as inhibitors of adenovirus replication

2-[2-Benzoylamino)benzoylamino]benzoic acid (1) was previously identified as a potent and nontoxic antiadenoviral compound (Antimicrob. Agents Chemother. 2010, 54, 3871). Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds and that the direction of the amide bonds (as in 1) is obligatory. Some variability in the N-terminal moiety was tolerated, but benzamides appear to be preferred. The substituents on the middle and C-terminal rings were varied, resulting in two potent inhibitors, 35g and 35j, with EC50 = 0.6 μM and low cell toxicity.