1352203-70-3

Basic information

• Product Name: (1,2-cis-2,3-cis-3,4-cis)-1,3-bis[4-{[(t-butoxy)carbonyl]amino}benzamido]-2,4-diphenylcyclobutane-1,3-dicarboxylic acid
• CAS NO: 1352203-70-3
• Molecular Weight: 764.832
• Mol File: 1352203-70-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1,2-cis-2,3-cis-3,4-cis)-1,3-bis[4-{[(t-butoxy)carbonyl]amino}benzamido]-2,4-diphenylcyclobutane-1,3-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (1,2-cis-2,3-cis-3,4-cis)-1,3-bis[4-{[(t-butoxy)carbonyl]amino}benzamido]-2,4-diphenylcyclobutane-1,3-dicarboxylic acid(1352203-70-3)
• EPA Substance Registry System: (1,2-cis-2,3-cis-3,4-cis)-1,3-bis[4-{[(t-butoxy)carbonyl]amino}benzamido]-2,4-diphenylcyclobutane-1,3-dicarboxylic acid(1352203-70-3)

Safety Data

• Hazardous Substances Data: 1352203-70-3(Hazardous Substances Data)

Upstream product

• 1352204-30-8 (Z)-2-[4-{[(t-butoxy)carbonyl]amino}phenyl]-4-benzylidene-5(4H)-oxazolone 

Relevant articles and documents

Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor

A novel cyclobutane class of nonpeptidic glucagon-like peptide-1 (GLP-1) receptor agonists, exemplified by 3, was identified using receptor binding and multiple response element/cAMP response element (MRE/CRE)-driven reporter gene assays. The structures of 3 and its three isomers were elucidated by NMR, HRESIMS, and X-ray crystallography. A series of structural modifications were also made based on the core structure of 3 with different substitution groups at the west and east ends. Among these analogues, compound 16 was found to be 4- to 5-fold more potent than 3 both in vitro and in vivo.