1352288-09-5

Basic information

• Product Name: 4-chloro-N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamide
• Synonyms: 4-chloro-N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamide
• CAS NO: 1352288-09-5
• Molecular Weight: 326.686
• Mol File: 1352288-09-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamide(1352288-09-5)
• EPA Substance Registry System: 4-chloro-N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamide(1352288-09-5)

Safety Data

• Hazardous Substances Data: 1352288-09-5(Hazardous Substances Data)

Upstream product

• 98-60-2 4-chlorobenzenesulfonyl chloride 

Relevant articles and documents

Design and synthesis of new N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes

A rational approach was used to synthesize a new set of 15 1H-1,2,4-triazol-3-yl benzenesulfonamide derivatives with the aim of developing new antimalarial lead compounds. These derivatives were prepared in yields between 50% and 62%, and their structures were elucidated using IR, 1H-, 13C-, 19F-NMR, MS and elemental analysis. A docking study based on sulfonamides previously used against malaria identified trifluoromethyl-substituted derivatives to be the best lead compounds for new antimalarial drug development.