1352428-56-8Relevant articles and documents
The discovery of novel cyclohexylamide CCR2 antagonists
Lanter, James C.,Markotan, Thomas P.,Zhang, Xuqing,Subasinghe, Nalin,Kang, Fu-An,Hou, Cuifen,Singer, Monica,Opas, Evan,McKenney, Sandra,Crysler, Carl,Johnson, Dana,Molloy, Christopher J.,Sui, Zhihua
, p. 7496 - 7501 (2012/02/13)
As a result of further SAR studies on a piperidinyl piperidine scaffold, we report the discovery of compound 44, a potent, orally bioavailable CCR2 antagonist. While having some in vitro hERG activity, this molecule was clean in an in vivo model of QT pro