1352559-53-5Relevant articles and documents
METHOD FOR PRODUCING N-SUBSTITUTED-2-AMINO-4-(HYDROXYMETHYLPHOSPHINYL)-2-BUTENOIC ACID
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Page/Page column 7-8, (2012/12/13)
Provided is a method for producing a compound expressed by the following formula (3): [where R1 represents a hydrogen atom or C1-4 alkyl group, and R2 represents C1-4 alkyl group, C1-4 alkoxy group, aryl group, aryloxy group or benzyloxy group], the method comprising a reaction of dehydro-condensing a compound expressed by the following formula (1): [where R1 represents the same meaning as defined above], and a compound expressed by the following formula (2): [where R2 represents the same meaning as defined above], while being converted to a desired geometric isomer in the presence or absence of an acid catalyst, under a condition that an organic solvent to be used for the reaction is a mixed solvent of acetic acid and a solvent selected from the group consisting of toluene, xylene and chlorobenzene, and a mixing ratio of acetic acid to the other solvent is from 1:3 to 1:5 in volume, wherein the reaction is conducted under heating and refluxing.