1352613-37-6

Basic information

• Product Name: (S)-4-(methoxyamino)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl methane-sulfonate
• Synonyms: (S)-4-(methoxyamino)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl methane-sulfonate
• CAS NO: 1352613-37-6
• Molecular Weight: 341.308
• Mol File: 1352613-37-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-(methoxyamino)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl methane-sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(methoxyamino)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl methane-sulfonate(1352613-37-6)
• EPA Substance Registry System: (S)-4-(methoxyamino)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl methane-sulfonate(1352613-37-6)

Safety Data

• Hazardous Substances Data: 1352613-37-6(Hazardous Substances Data)

Upstream product

• 1352613-36-5 (S)-3-hydroxy-N-methoxy-4-(2,4,5-trifluorophenyl)butanamide 
• 124-63-0 methanesulfonyl chloride 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 1283096-74-1 (S)-3-hydroxy-4-(2,4,5-trifluorophenyl)butanenitrile 
• 868071-17-4 3(S)-4-(2,4,5-trifluorophenyl)-3-hydroxybutanoic acid 
• 1246960-15-5 (S)-1-chloro-3-(2,4,5-trifluorophenyl)propan-2-ol 
• 1352613-29-6 (S)-ethyl 3-hydroxy-4-(2,4,5-trifluorophenyl)butanoate 

Downstream Products

• 486460-32-6 sitagliptin 
• 1352613-39-8 (R)-1-methoxy-4-(2,4,5-trifluorobenzyl)azetidin-2-one 
• 1352613-40-1 (R)-3-(methoxyamino)-4-(2,4,5-trifluorophenyl)butanoic acid 
• 1352613-41-2 (R)-3-(methoxyamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one 

Relevant articles and documents

Process for the synthesis of beta-amino acids and derivatives thereof

The present invention relates to a process for the preparation of β-amino acids and derivatives thereof, which is especially suited for gliptins and particularly sitagliptin. A key step makes use of suitably derivatized epoxides or aziridines, which owing to a chirality provides a source of chirality for intermediates which are suitable for building up β-amino acids and similar compounds, in particular in the construction of the sitagliptin molecule.