1352801-45-6

Basic information

• Product Name: (4-bromophenyl)formamido 2,2-dimethylpropanoate
• Synonyms: (4-bromophenyl)formamido 2,2-dimethylpropanoate
• CAS NO: 1352801-45-6
• Molecular Weight: 300.152
• Mol File: 1352801-45-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (4-bromophenyl)formamido 2,2-dimethylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (4-bromophenyl)formamido 2,2-dimethylpropanoate(1352801-45-6)
• EPA Substance Registry System: (4-bromophenyl)formamido 2,2-dimethylpropanoate(1352801-45-6)

Safety Data

• Hazardous Substances Data: 1352801-45-6(Hazardous Substances Data)

Upstream product

• 35657-35-3 O-Pivaloylhydroxylamine hydrochloride 
• 586-75-4 4-chlorobenzoyl chloride 
• 586-76-5 4-Bromobenzoic acid 
• 1293990-73-4 O-pivaloylhydroxylamine trifluoromethanesulfonate salt 

Downstream Products

• 1352801-62-7 4-bromo-2-morpholin-4-yl-N-(pivaloyloxy)benzamide 
• 17437-52-4 4-bromo-N-(triphenyl-λ⁵-phosphanylidene)benzamide 
• 82827-09-6 6-bromo-2H-isoquinoline-1-one 
• 1610376-35-6 4-bromo-N-(pivaloyloxy)-2-((triisopropylsilyl)ethynyl)benzamide 
• 1610376-44-7 4-bromo-2-(3,3-dimethylbut-1-yn-1-yl)-N-(pivaloyloxy)benzamide 
• 1427218-27-6 methyl 6-bromo-3-oxo-1-phenylisoindoline-1-carboxylate 
• 1400655-70-0 (Z)-6-bromo-4-(cyclohexylmethylene)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant articles and documents

Synthesis of sulfimides and N-Allyl-N-(thio)amides by Ru(II)catalyzed nitrene transfer reactions of N-acyloxyamides

The N-acyloxyamides were employed as effective N-acyl nitrene precursors in reactions with thioethers under the catalysis of a commercially available Ru(II) complex, from which a variety of sulfimides were synthesized efficiently and mildly. If an allyl group is contained in the thioether precursor, the [2,3]-sigmatropic rearrangement of the sulfimide occurs simultaneously and the N-allyl-N-(thio)amides were obtained as the final products. Preliminary mechanistic studies indicated that the Ru-nitrenoid species should be a key intermediate in the transformation.

Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD)

This study describes general synthesis aspects of fragments for FBDD, as illustrated by the dihydroisoquinolones 1-3. Previous Rh(iii) methodology is extended to incorporate amines, heteroatoms (N and S), and substituents (halogen, ester) as potential binding groups and/or synthetic growth points for fragment-to-lead elaboration.

Rhodium-catalyzed C-H alkynylation of arenes at room temperature

The rhodium(III)-catalyzed ortho C-H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation. Hot rhod: A rhodium-catalyzed, electronically reversed Sonogashira reaction between unbiased arenes and the hypervalent iodine reagent 1 proceeds through C-H activation. This reaction displays excellent functional-group tolerance and high efficiency, and thus opens a new synthetic pathway to access functionalized alkynes. Cp=C5Me5, DCE=1,2-dichloroethane, Piv=pivaloyl, TIPS=triisopropylsilyl.