1352825-35-4

Basic information

• Product Name: (S)-3-(2-hydroxyphenyl)-2-(5-methoxybenzofuran-2-carboxamido)propanoic acid
• Synonyms: (S)-3-(2-hydroxyphenyl)-2-(5-methoxybenzofuran-2-carboxamido)propanoic acid
• CAS NO: 1352825-35-4
• Molecular Weight: 355.347
• Mol File: 1352825-35-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-(2-hydroxyphenyl)-2-(5-methoxybenzofuran-2-carboxamido)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(2-hydroxyphenyl)-2-(5-methoxybenzofuran-2-carboxamido)propanoic acid(1352825-35-4)
• EPA Substance Registry System: (S)-3-(2-hydroxyphenyl)-2-(5-methoxybenzofuran-2-carboxamido)propanoic acid(1352825-35-4)

Safety Data

• Hazardous Substances Data: 1352825-35-4(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 35175-73-6 (S)-N-(2-oxochroman-3-yl)benzamide 
• 2549-08-8 3-benzamidocoumarin 
• 10242-08-7 5-methoxybenzofuran-2-carboxylic acid 

Relevant articles and documents

Rhodium-Catalyzed Asymmetric Hydrogenation of 3-Benzoylaminocoumarins for the Synthesis of Chiral 3-Amino Dihydrocoumarins

An asymmetric hydrogenation of 3-benzoylaminocoumarins was achieved for the first time using our BridgePhos-Rh catalytic system, providing chiral 3-amino dihydrocoumarins in high yields (up to 98 %) and with excellent enantioselectivities (up to 99.7 % ee). The relationship between the enantioselectivities of the hydrogenations and the dihedral angles and the resulting π-π stacking effects of the BridgePhos-Rh complexes, which were determined by X-ray diffraction analysis, are discussed. The corresponding hydrogenated products allow for many transformations, providing several chiral skeletons with important physiological and pharmacological activities.