1352826-60-8

Basic information

• Product Name: 1-(2-bromomethylbenzyl)-3-hydroxyiminomethylpyridinium bromide
• Synonyms: 1-(2-bromomethylbenzyl)-3-hydroxyiminomethylpyridinium bromide
• CAS NO: 1352826-60-8
• Molecular Weight: 386.086
• Mol File: 1352826-60-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-bromomethylbenzyl)-3-hydroxyiminomethylpyridinium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromomethylbenzyl)-3-hydroxyiminomethylpyridinium bromide(1352826-60-8)
• EPA Substance Registry System: 1-(2-bromomethylbenzyl)-3-hydroxyiminomethylpyridinium bromide(1352826-60-8)

Safety Data

• Hazardous Substances Data: 1352826-60-8(Hazardous Substances Data)

Upstream product

• 873-69-8 2-pyridinealdoxime 
• 626-15-3 1,3-bis-(bromomethyl)benzene 

Relevant articles and documents

Monooxime bispyridinium reactivators bearing xylene linker synthesis and in vitro evaluation on model of organophosphate-inhibited acetylcholinesterase

Nine novel mono-oxime reactivators bearing xylene linker were synthesized in an effort to improve previously prepared xylene bisoximes and monocarbamoyl-monooximes. The novel compounds were tested in vitro on the model of tabun-, paraoxon-, methylparaoxon

Monooxime-monocarbamoyl bispyridinium xylene-linked reactivators of acetylcholinesterase - synthesis, in vitro and toxicity evaluation, and docking studies

Acetylcholinesterase (AChE) reactivators are crucial antidotes to organophosphate intoxication. A new series of 26 monooxime-monocarbamoyl xylene-linked bispyridinium compounds was prepared and tested in vitro, along with known reactivators (pralidoxime, HI-6, obidoxime, trimedoxime, methoxime, K107, K108 and K203), on a model of tabun- and paraoxon-, methylparaoxon- and DFP-inhibited human erythrocyte AChE. Although their ability to reactivate tabun-inhibited AChE did not exceed that of the previously known compounds, some newly prepared compounds showed promising reactivation of pesticide-inhibited AChE. The acute toxicity of the 0ovel compounds was also determined. Docking studies using tabun-inhibited AChE were performed for three compounds of interest. The structure-activity relationship (SAR) study confirmed the apparent influence of the xylene linkage and carbamoyl moiety on the reactivation ability and toxicity of the agents.