135304-82-4Relevant articles and documents
Acid-Base Properties of 5-Hydroxy-1,3,6-trimethyluracil in Aqueous Solutions
Gimadieva, A. R.,Ivanov, S. P.,Khazimullina, Yu. Z.,Nugumanov, T. R.,Petrova, S. F.
, (2020)
Abstract: 5-Hydroxy-1,3,6-trimethyluracil has been studied using 1H, 13C, and 15N NMR as well as UV spectroscopy. The constants and thermodynamic characteristics of its acid-base equilibrium in aqueous solutions have been
Studies on the chemistry of pyrimidine derivatives with dimethyldioxirane: Synthesis, cytotoxic effect and antiviral activity of new 5,6-oxiranyl-5,6-dihydro and 5-hydroxy-5,6-dihydro-6-substituted uracil derivatives and pyrimidine nucleosides
Saladino, Raffaele,Bernini, Roberta,Crestini, Claudia,Mincione, Enrico,Bergamini, Alberto,Marini, Stefano,Palamara, Anna Teresa
, p. 7561 - 7578 (2007/10/02)
The oxidation of uracil derivatives and pyrimidine nucleosides performed in CH2Cl2 with dimethyldioxirane afforded new 5,6-oxiranyl-5,6-dihydro and cis-/trans-5,6-dihvdroxv-5,6-dihydro-derivatives. When the oxidations were performed in the presence of methanol as nucleophile cis- and trans- 5-hydroxy-6-methoxy-5,6-dihydro derivatives were obtained in acceptable yields. Cis- and trans-1,3- dimethyl-5-hydroxy-6-alkylamino-5,6-dihydro uracils were obtained by nucleophilic ring opening of the 1,3-dimethyl-5,6-oxiranyl-5,6-dihydro uracil in the purified form. Interestingly some of the new title products revealed low cytotoxicity and selective antiviral activity against DNA and RNA Viruses. In particular, compound 17b shows a strong and selective inhibition of the Sendai virus with lower effect on Herpes Simplex-1 virus. Compound 17b is also able to slightly inhibit HIV-1 virus at high concentrations, but in this case a cytotoxic effect was observed.
