135321-95-8

Basic information

• Product Name: 5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID
• Synonyms: 5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID;5-[[(1,1-DiMethylethoxy)carbonyl]aMino]-2-hydroxy-benzoic Acid
• CAS NO: 135321-95-8
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.25
• Product Categories: Aromatics Compounds;Aromatics;Miscellaneous Reagents
• Mol File: 135321-95-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 279-280°C
• Boiling Point: 367.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.337±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 3.12±0.10(Predicted)
• CAS DataBase Reference: 5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID(135321-95-8)
• EPA Substance Registry System: 5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID(135321-95-8)

Safety Data

• Hazardous Substances Data: 135321-95-8(Hazardous Substances Data)

Usage

Description

5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID, also known as 5-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-hydroxybenzoic Acid, is a pinky-grey solid that is an impurity derived from the synthesis of Mesalamine (M258100). It is a chemical compound with a unique structure that has potential applications in various industries.

Uses

Used in Pharmaceutical Industry:
5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID is used as an impurity in the synthesis of Mesalamine for [application reason]. Mesalamine is a medication used to treat ulcerative colitis and Crohn's disease, and the presence of this impurity may affect the purity and efficacy of the final product.
Used in Chemical Research:
5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID is used as a research compound for [application reason]. Its unique chemical structure and properties make it a valuable subject for studying various chemical reactions and potential applications in the field of chemistry.
Used in Quality Control:
5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID is used as a reference material for quality control in the pharmaceutical industry for [application reason]. By analyzing the presence and concentration of this impurity in Mesalamine synthesis, manufacturers can ensure the quality and safety of the final product.
Used in Environmental Monitoring:
5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID is used as a marker for environmental monitoring and assessment for [application reason]. Its detection in the environment can provide valuable information about the presence of industrial pollutants and the need for remediation efforts.
Used in Material Science:
5-(N-TERT-BUTOXYCARBONYLAMINO)SALICYLIC ACID is used as a component in the development of new materials for [application reason]. Its unique properties may contribute to the creation of advanced materials with specific characteristics, such as improved strength, durability, or chemical resistance.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 89-57-6 5-Aminosalicylic Acid 

Downstream Products

• 327037-22-9 5-[N-(tert-butoxycarbonyl)amino]-N-(2-pyridin-2-ylethyl)salicylamide 
• 327037-23-0 5-[N-(tert-butoxycarbonyl)amino]-N-(3-phenyl-1-propyl)salicylamide 
• 327037-19-4 5-[N-(tert-butoxycarbonyl)amino]-N-(4-chloro-β-phenethyl)salicylamide 
• 2387-23-7 1,3-Dicyclohexylurea 
• 257626-07-6 5-tert-Butyloxy-carbonylamino-2-hydroxy-benzoic-(4-bromo-butyl)-Ester Acid 
• 327037-16-1 5-[N-(tert-butoxycarbonyl)amino]-N-(4-bromo-β-phenethyl)salicylamide 
• 1351504-02-3 5-amino-2-(butyryloxy)benzoic acid hydrochloride 

Relevant articles and documents

Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways

The multiple inhibition of biological targets involved in pro-inflammatory eicosanoid biosynthesis represents an innovative strategy for treating inflammatory disorders in light of higher efficacy and safety. Herein, following a multidisciplinary protocol

ACYLATED ACTIVE AGENTS AND METHODS OF THEIR USE FOR THE TREATMENT OF AUTOIMMUNE DISORDERS

Disclosed herein are acylated active agents (e.g., acylated catechin polyphenols, acylated carotenoids, acylated mesalamines, acylated sugars, acylated shikimic acids, acylated ellagic acid, acylated ellagic acid analogue, and acylated hydroxybenzoic acids), active agent combinations (e.g., with a second agent that is a fatty acid) and methods of their use, e.g., for modulating an autoimmunity marker or for treating an autoimmune disorder.

Synthesis and antitumor activity of ATB-429 derivatives containing a nitric oxide-releasing moiety

A series of novel ATB-429 (an anti-inflammatory candidate) derivatives containing a nitric oxide (NO)-releasing moiety were designed, synthesized and evaluated for their in vitro activity against six human cancer cell lines. Our results reveal that phenyl