135324-40-2

Basic information

• Product Name: 7-Isopropyl-6-phenyl-4-oxa-7,7a-diazaperhydroindan
• CAS NO: 135324-40-2
• Molecular Weight: 246.352
• Mol File: 135324-40-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-Isopropyl-6-phenyl-4-oxa-7,7a-diazaperhydroindan(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Isopropyl-6-phenyl-4-oxa-7,7a-diazaperhydroindan(135324-40-2)
• EPA Substance Registry System: 7-Isopropyl-6-phenyl-4-oxa-7,7a-diazaperhydroindan(135324-40-2)

Safety Data

• Hazardous Substances Data: 135324-40-2(Hazardous Substances Data)

Upstream product

• 112211-92-4 (R)-N-(2-Hydroxy-1-phenylethyl)-N-isopropylamine 
• 6139-84-0 4-chlorobutyraldehyde 
• 135324-38-8 (R)-N-(2-Hydroxy-1-phenylethyl)-N-isopropylhydrazine 

Downstream Products

• 135324-65-1 (1'R,2R)-1--2-phenylpyrrolidine 
• 135324-42-4 (R)-2-Benzyl-1-isopropylaminopyrrolidine 
• 135324-64-0 (1'R,2R)-2-Benzyl-1-pyrrolidine 
• 135324-63-9 (1'R,2S)-2-Ethyl-1-pyrrolidine 
• 135324-62-8 (1'R,2S)-1--2-methylpyrrolidine 

Relevant articles and documents

Organometallic reactions characteristic of chiral heterocyclic compounds: Synthesis and stereo-selective Grignard reaction of chiral 4-oxa-7,7a-diazaperhydroindans

New heterocyclic compounds, 6-phenyl-4-oxa-7,7a-diazaperhydroindans (5 and 6), were synthesized by condensation of chiral 2-hydroxyethylhydrazines prepared from (R)-phenylglycinol with γ-chlorobutyraldehyde. The stereoselective Grignard reaction of 5 and 6 proceeded to give chiral 2-substituted 1-[N-(2-hydroxy-1-phenylethyl)amino]pyrrolidines (7a-d and 8a-d). The structures of these products were determined by comparison with authentic samples, and the reaction mechanism is proposed to involve an intermediate iminium salt.