1353562-24-9

Basic information

• Product Name: N-(3,5-dimethoxyphenyl)formamide
• Synonyms: N-(3,5-dimethoxyphenyl)formamide
• CAS NO: 1353562-24-9
• Molecular Weight: 181.191
• Mol File: 1353562-24-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: N-(3,5-dimethoxyphenyl)formamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-dimethoxyphenyl)formamide(1353562-24-9)
• EPA Substance Registry System: N-(3,5-dimethoxyphenyl)formamide(1353562-24-9)

Safety Data

• Hazardous Substances Data: 1353562-24-9(Hazardous Substances Data)

Upstream product

• 77287-34-4 formamide 
• 10272-07-8 3.5-dimethoxyaniline 
• 710311-79-8 N-hydroxy-3,5-dimethoxybenzamide 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 2258-42-6 formyl acetic anhydride 
• 64-18-6 formic acid 
• 922-67-8 propynoic acid methyl ester 
• 68-12-2 N,N-dimethyl-formamide 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 165459-69-8 (3,5-dimethoxyphenyl)isonitrile 
• 1396790-06-9 N-(2-bromo-3,5-dimethoxyphenyl)formamide 
• 1396790-07-0 N-(4-bromo-3,5-dimethoxyphenyl)formamide 
• 90557-59-8 4,6-dimethoxybenzimidazole 
• 1075748-44-5 1,2-diamino-3,5-dimethoxybenzene 
• 192696-43-8 3,5-Dimethoxy-2-nitrobenzenamine 

Relevant articles and documents

Catalyst-Free Transamidation of Aromatic Amines with Formamide Derivatives and Tertiary Amides with Aliphatic Amines

A simple catalyst- and promoter-free protocol has been developed for the transamidation of weakly nucleophilic aromatic amines with formamide derivatives and low-reactivity tertiary amides with aliphatic amines. This strategy is advantageous because no catalyst or promoters are needed, no additives are required, separation and purification is easy, and the reaction is scalable. Significantly, this strategy was further applied to synthesize several pharmaceutical molecules on a gram scale, and excellent yields were achieved.

KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines

This work discloses transamidation of primary and tertiary amides with a range of aryl, heteroaryl, and aliphatic amines using potassium tert-butoxide. The reaction proceeds at room temperature under transition-metal-free conditions providing secondary amides in high yields. Moreover, reaction of cyclopropyl amine with tertiary amides proceeds with ring-opening to provide a rapid access to enamides.

Aerobic radical-cascade cycloaddition of isocyanides, selenium and imidamides: Facile access to 1,2,4-selenadiazoles under metal-free conditions

A novel and facile metal-free method for the green synthesis of 1,2,4-selenadiazol-5-amine derivatives through the aerobic radical-cascade multi-component reactions of isocyanides, selenium powder and imidamides is reported herein. O2 in the air was employed as the green oxidant to achieve the cycloaddition with the generation of H2O as the sole by-product. It also features good functional group compatibility and broad substrate scope. In addition, this method was successfully applied to the functionalization of biologically active molecules.