1353717-61-9

Basic information

• Product Name: C₁₆H₁₆O₄S
• CAS NO: 1353717-61-9
• Molecular Weight: 304.367
• Mol File: 1353717-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₆O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₆O₄S(1353717-61-9)
• EPA Substance Registry System: C₁₆H₁₆O₄S(1353717-61-9)

Safety Data

• Hazardous Substances Data: 1353717-61-9(Hazardous Substances Data)

Upstream product

• 5751-80-4 thiophene-3-carboxylic acid ethyl ester 
• 619-42-1 4-methoxycarbonylphenyl bromide 

Relevant articles and documents

Palladium-catalysed C2 or C5 direct arylation of 3-substituted thiophenes with aryl bromides

The Pd(OAc)2/dppb system was found to be an efficient catalyst for the direct arylation of 3-substituted thiophene derivatives. The regioselectivity of the arylation strongly depends on the thiophene substituent and also on the nature of the aryl bromide. When using 3-formyl, 3-cyano, 3-methyl, 3-hydroxymethyl or 3-bromothiophene, the 2-arylated thiophenes were obtained with 76-95% regioselectivity; whereas, the arylation of 3-formylthiophene diethylacetal or 3-acetylthiophene gave the 5-arylated thiophenes with 52-90% regioselectivity. The use of congested aryl bromides favours the arylation at C5. These reactions were performed using only 0.1 mol% of catalyst. Moreover, this procedure has been found to be tolerant to a variety of functional groups on the aryl bromide such as formyl, propionyl, benzoyl, nitrile, and nitro. Georg Thieme Verlag Stuttgart.