135380-53-9 Usage
General Description
2,7-Diazaspiro[4.4]nonane, 2-methyl- is a chemical compound with a unique spirocyclic structure containing two nitrogen atoms. It is commonly used as a building block in organic synthesis, particularly in the pharmaceutical industry for the preparation of various heterocyclic compounds. This chemical is also known for its use in the synthesis of new therapeutic agents and has shown potential as a lead compound for the development of new drugs. Additionally, it has demonstrated biological activity, making it a subject of interest in medicinal chemistry research. Overall, 2,7-Diazaspiro[4.4]nonane, 2-methyl- is a versatile compound with potential applications in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 135380-53-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,3,8 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 135380-53:
(8*1)+(7*3)+(6*5)+(5*3)+(4*8)+(3*0)+(2*5)+(1*3)=119
119 % 10 = 9
So 135380-53-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H16N2/c1-10-5-3-8(7-10)2-4-9-6-8/h9H,2-7H2,1H3
135380-53-9Relevant articles and documents
Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds
Weinberg, Kamil,Stoit, Axel,Kruse, Chris G.,Haddow, Mairi F.,Gallagher, Timothy
, p. 4694 - 4707 (2013/07/04)
The synthesis and differential substitution/protection of a series of spirodiamine scaffolds are described. Methods for selective access to the two mono-N-methyl isomers based on 2,7-diazaspiro[4.5]decane are also described. Key precursors associated with this chemistry are prone to rearrangement and methods for circumventing this issue are reported. While direct mono-carbamoylation (Boc) was not efficient, selective deprotection of doubly Boc-protected derivatives derived from symmetrical diamines provided mono-Boc variants. N-Arylation, exemplified by a series of monosubstituted spirodiamines incorporating the 2-chloro-5-pyridyl moiety, which is a privileged nicotinic agonist substructure, has also been carried out to provide monoarylated secondary and tertiary spirodiamines variants.
