1353859-02-5

Basic information

• Product Name: 5-chloro-3-(1-(5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)ethylidene)indolin-2-one
• CAS NO: 1353859-02-5
• Molecular Weight: 475.975
• Mol File: 1353859-02-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-3-(1-(5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)ethylidene)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-(1-(5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)ethylidene)indolin-2-one(1353859-02-5)
• EPA Substance Registry System: 5-chloro-3-(1-(5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)ethylidene)indolin-2-one(1353859-02-5)

Safety Data

• Hazardous Substances Data: 1353859-02-5(Hazardous Substances Data)

Upstream product

• 179055-22-2 N-methyl-N-methoxy-5-bromofuran-2-carboxamide 
• 99769-19-4 [3-(methoxycarbonyl)phenyl]boronic acid 
• 1202918-50-0 3-(5-acetylfuran-2-yl)benzoic acid 
• 1202918-49-7 3-(5-acetylfuran-2-yl)benzoic acid methyl ester 
• 17630-75-0 5-chloro-indolin-2-one 
• 1202918-51-1 1-{5-[3-(4-methyl[1,4]diazepane-1-carbonyl)phenyl]furan-2-yl}ethanone 
• 585-70-6 5-bromo-furan-2-carboxylic acid 
• 3199-50-6 1-(5-bromofuran-2-yl)ethanone 

Relevant articles and documents

Discovery of CX-6258. A potent, selective, and orally efficacious pan-pim kinases inhibitor

Structure-activity relationship analysis in a series of 3-(5-((2-oxoindolin-3-ylidene)methyl)furan-2-yl)amides identified compound 13, a pan-Pim kinases inhibitor with excellent biochemical potency and kinase selectivity. Compound 13 exhibited in vitro synergy with chemotherapeutics and robust in vivo efficacy in two Pim kinases driven tumor models.